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Original research
hossein ghahvehchian
Tehran University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6498-1408
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective: To describe clinical and flow cytometry findings of an unusual case of hyper immunoglobulin E syndrome with severe ophthalmic involvements.
Method: A Case report.
Report: A 13-year-old boy was reported with infectious dermatitis, dental sinus with positive Actinomyces israelii culture, severe blepharitis, follicular conjunctivitis, and dysmorphic, vascularized cornea with no light perception visual acuity in both eyes. In immunophenotyping with the flow cytometry, a decrease in T-cell markers (CD2, CD3, CD4, CD5, CD7) was prominent. CD34 and CD117, hematopoietic stem cell, and circulating progenitor cell markers were negative.
Conclusion: This is the first known reported case of flow cytometry findings, especially the lack of CD34+ and CD114+ cells in hyper immunoglobulin E patient with severe anterior and posterior segment involvement. Proper antimicrobial interventions are important in infectious flare-ups.
Keywords
Hyperimmunoglobulin E syndrome, ophthalmic complication, flow cytometry
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Original research
hossein ghahvehchian
Tehran University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6498-1408
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 05 Jan, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective: To describe clinical and flow cytometry findings of an unusual case of hyper immunoglobulin E syndrome with severe ophthalmic involvements.
Method: A Case report.
Report: A 13-year-old boy was reported with infectious dermatitis, dental sinus with positive Actinomyces israelii culture, severe blepharitis, follicular conjunctivitis, and dysmorphic, vascularized cornea with no light perception visual acuity in both eyes. In immunophenotyping with the flow cytometry, a decrease in T-cell markers (CD2, CD3, CD4, CD5, CD7) was prominent. CD34 and CD117, hematopoietic stem cell, and circulating progenitor cell markers were negative.
Conclusion: This is the first known reported case of flow cytometry findings, especially the lack of CD34+ and CD114+ cells in hyper immunoglobulin E patient with severe anterior and posterior segment involvement. Proper antimicrobial interventions are important in infectious flare-ups.
Figure 1
Figure 2
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