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Research article
Yonghui Liu
the First Affiliated Hospital of Guangxi University of Chinese Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1738-4149
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Abstract Background ：Epilepsy is one of great health burden in the world, deeply effects epilepsy population’s mental and physical health,some can totally recover through effective treatment, while some others are difficult to recover even have life risks when seizure attacks. In that case,we explore the effects of cerebrospinal fluid AMPA receptor levels on the clinical efficacy of lamotrigine in the treatment of epilepsy.We believe our work might have an implication in the treatment of epilepsy. Methods ：The 70 cases of epilepsy in our hospital were diagnosed and selected in this study from December 2016 to October 2018; The AMPA receptor content of patients in cerebrospinal fluid were determined by enzyme linked immunosorbent assay; The patients were paired into high AMPA group (n=34) and low AMPA group (n=36) according to the median value at 4.08 ng/ml. Clinical efficacy and the incidence of adverse reactions were compared between two groups. Results ：Before treatment, there was no significant difference in seizure frequency between the two groups (P>0.05); After treatment for 6 months and 12 months, the seizure frequencies of the two groups were gradually reduced (P<0.05); Moreover, the number of seizures in the low AMPA group were significantly less than those in the high AMPA group (P<0.05); The response rate of high AMPA group was 79.41%, which was significantly lower than that in the low group AMPA (χ2=6.055, P=0.048); The improvement on the efficiency of electroencephalogram in the high AMPA group was 67.65%, which was significantly lower than that in the low AMPA group (χ2=4.686, P=0.030); However, there was no significant on the incidence of adverse reactions between two groups (χ2=0.202, P=0.653). Conclusions： AMPA receptor plays an important role in the development of epilepsy and the low AMPA receptor level patients were more efficacies to the treatment of lamotrigine. Keywords：Lamotrigine; Epilepsy; AMPA receptor.
Keywords
Lamotrigine, Epilepsy, AMPA receptor
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Yonghui Liu
the First Affiliated Hospital of Guangxi University of Chinese Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1738-4149
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
The most recent version of this article is available here.
No community comments so far
Version 1
Posted 19 Jun, 2019
No comments provided
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Neurology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The most recent version of this article is available here.
Abstract Background ：Epilepsy is one of great health burden in the world, deeply effects epilepsy population’s mental and physical health,some can totally recover through effective treatment, while some others are difficult to recover even have life risks when seizure attacks. In that case,we explore the effects of cerebrospinal fluid AMPA receptor levels on the clinical efficacy of lamotrigine in the treatment of epilepsy.We believe our work might have an implication in the treatment of epilepsy. Methods ：The 70 cases of epilepsy in our hospital were diagnosed and selected in this study from December 2016 to October 2018; The AMPA receptor content of patients in cerebrospinal fluid were determined by enzyme linked immunosorbent assay; The patients were paired into high AMPA group (n=34) and low AMPA group (n=36) according to the median value at 4.08 ng/ml. Clinical efficacy and the incidence of adverse reactions were compared between two groups. Results ：Before treatment, there was no significant difference in seizure frequency between the two groups (P>0.05); After treatment for 6 months and 12 months, the seizure frequencies of the two groups were gradually reduced (P<0.05); Moreover, the number of seizures in the low AMPA group were significantly less than those in the high AMPA group (P<0.05); The response rate of high AMPA group was 79.41%, which was significantly lower than that in the low group AMPA (χ2=6.055, P=0.048); The improvement on the efficiency of electroencephalogram in the high AMPA group was 67.65%, which was significantly lower than that in the low AMPA group (χ2=4.686, P=0.030); However, there was no significant on the incidence of adverse reactions between two groups (χ2=0.202, P=0.653). Conclusions： AMPA receptor plays an important role in the development of epilepsy and the low AMPA receptor level patients were more efficacies to the treatment of lamotrigine. Keywords：Lamotrigine; Epilepsy; AMPA receptor.
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