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Research Article
Hae-Young Park
Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea
Corresponding Author
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We investigated the characteristics of localized vessel density defects (VD) either in the deep or superficial vascular layer of normal-tension glaucoma patients using optical coherence tomography angiography (OCTA). In this retrospective, cross-sectional study, 74 eyes with localized retinal nerve fiber layer (RNFL) defect were included. The relationships between the widths of the VD in the superficial and deep layer and ocular factors were evaluated. Eyes with greater deep VD were significantly older (P = 0.023). Baseline and treated IOPs were significantly related to the width of the deep VD (P=0.009 and 0.014, respectively). By contrast, average ganglion cell inner plexiform layer thickness (GCIPLT) was substantially related to the width of the superficial VD (Both Ps=0.004). In logistic regression analysis, aging was noticeably associated with wider deep VD, whereas worse pattern standard deviation (PSD) had a significant association with wider superficial VD (Both Ps=0.001). In sum, while changes of the superficial layer seemed an overall ramification of glaucomatous damages, the deep layer was more likely to be affected by factors related to ocular microcirculation, such as IOPs and older age. Thus, looking into the deep vascular layer using OCTA could identify risk factors related to the disturbance in ocular microcirculation.
Keywords
localized vessel density defect, normal- tension glaucoma, superficial layer, deep layer, optical coherence tomography angiography
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CURRENT STATUS: Under Review
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Posted 15 Jan, 2021
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Editorial decision: Major revision
On 10 Mar, 2021
Reviews received
Received 09 Mar, 2021
Reviewers agreed
On 08 Mar, 2021
Reviews received
Received 15 Feb, 2021
Reviewers agreed
On 01 Feb, 2021
Reviewers invited
Invitations sent on 28 Jan, 2021
Editor assigned
On 27 Jan, 2021
Editor invited
On 12 Jan, 2021
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On 12 Jan, 2021
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On 30 Dec, 2020
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A new preprint design is coming!
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Hae-Young Park
Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 15 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 10 Mar, 2021
Reviews received
Received 09 Mar, 2021
Reviewers agreed
On 08 Mar, 2021
Reviews received
Received 15 Feb, 2021
Reviewers agreed
On 01 Feb, 2021
Reviewers invited
Invitations sent on 28 Jan, 2021
Editor assigned
On 27 Jan, 2021
Editor invited
On 12 Jan, 2021
Submission checks complete
On 12 Jan, 2021
First submitted
On 30 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
We investigated the characteristics of localized vessel density defects (VD) either in the deep or superficial vascular layer of normal-tension glaucoma patients using optical coherence tomography angiography (OCTA). In this retrospective, cross-sectional study, 74 eyes with localized retinal nerve fiber layer (RNFL) defect were included. The relationships between the widths of the VD in the superficial and deep layer and ocular factors were evaluated. Eyes with greater deep VD were significantly older (P = 0.023). Baseline and treated IOPs were significantly related to the width of the deep VD (P=0.009 and 0.014, respectively). By contrast, average ganglion cell inner plexiform layer thickness (GCIPLT) was substantially related to the width of the superficial VD (Both Ps=0.004). In logistic regression analysis, aging was noticeably associated with wider deep VD, whereas worse pattern standard deviation (PSD) had a significant association with wider superficial VD (Both Ps=0.001). In sum, while changes of the superficial layer seemed an overall ramification of glaucomatous damages, the deep layer was more likely to be affected by factors related to ocular microcirculation, such as IOPs and older age. Thus, looking into the deep vascular layer using OCTA could identify risk factors related to the disturbance in ocular microcirculation.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
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