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Comparison of Recurrence of Non-muscle Invasive Bladder Carcinoma after Transurethral Resection with Hexaminolevulinate Photodynamic Diagnosis or Regular Cystoscopy
Fokke Hoogeveen
Isala
Corresponding Author
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Purpose: Comparison of recurrence of non-muscle invasive bladder carcinoma after transurethral resection with hexaminolevulinate photodynamic diagnosis (PDD) or regular white light cystoscopy (WLC).
Methods: We included patients with newly suspected non-muscle invasive bladder carcinoma in this retrospective cohort study and compared those undergoing transurethral resection by WLC and PDD. The primary outcome was the difference in the recurrence rate after 60 months’ follow-up, but we also stratified recurrence by risk groups. The mean recurrence-free survival was compared between the cohorts. Odds ratios or hazard ratios are reported with 95% confidence intervals.
Results: The WLC and PDD cohorts comprised 124 and 91 subjects, respectively. There were no significant differences in recurrence rates at 6 months (recurrence rate 9/123; 7.3%), 12 months (17/118; 14.4%), or 60 months (39/102; 38.2%), with odds ratios of 1.23 (0.48–3.25; P=0.64), 1.32 (0.67–2.62; P=0.42), and 1.12 (0.70–1.79; P=0.65), respectively. Further analysis showed no significant effect of PDD on recurrence by risk group or on mean recurrence-free survival (hazard ratio, 1.12; 0.70–1.79).
Conclusion: Photodynamic diagnosis with hexaminolevulinate did not reduce the recurrence of non-muscle invasive bladder carcinoma compared to standard white light cystoscopy when used for transurethral resection.
Keywords
hexaminolevulinate , photodynamic diagnosis (PDD), white light cystoscopy (WLC), carcinoma
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Comparison of Recurrence of Non-muscle Invasive Bladder Carcinoma after Transurethral Resection with Hexaminolevulinate Photodynamic Diagnosis or Regular Cystoscopy
Fokke Hoogeveen
Isala
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 06 Jan, 2021
No community comments so far
Review #9 received
Received 29 Jan, 2021
Review #16 received
Received 29 Jan, 2021
Review #17 received
Received 29 Jan, 2021
Review #1 received
Received 29 Jan, 2021
Review #8 received
Received 29 Jan, 2021
Review #7 received
Received 29 Jan, 2021
Review #11 received
Received 29 Jan, 2021
Review #10 received
Received 29 Jan, 2021
Review #18 received
Received 29 Jan, 2021
Reviewer #11 agreed
On 13 Jan, 2021
Reviewer #18 agreed
On 13 Jan, 2021
Reviewer #1 agreed
On 13 Jan, 2021
Reviewer #19 agreed
On 13 Jan, 2021
Reviewer #3 agreed
On 13 Jan, 2021
Reviewer #2 agreed
On 13 Jan, 2021
Reviewer #10 agreed
On 13 Jan, 2021
Reviewer #9 agreed
On 13 Jan, 2021
Reviewer #13 agreed
On 13 Jan, 2021
Reviewer #12 agreed
On 13 Jan, 2021
Reviewer #20 agreed
On 13 Jan, 2021
Reviewers invited
Invitations sent on 12 Jan, 2021
Editor assigned
On 12 Jan, 2021
Editor invited
On 01 Jan, 2021
Submission checks complete
On 01 Jan, 2021
First submitted
On 31 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: Comparison of recurrence of non-muscle invasive bladder carcinoma after transurethral resection with hexaminolevulinate photodynamic diagnosis (PDD) or regular white light cystoscopy (WLC).
Methods: We included patients with newly suspected non-muscle invasive bladder carcinoma in this retrospective cohort study and compared those undergoing transurethral resection by WLC and PDD. The primary outcome was the difference in the recurrence rate after 60 months’ follow-up, but we also stratified recurrence by risk groups. The mean recurrence-free survival was compared between the cohorts. Odds ratios or hazard ratios are reported with 95% confidence intervals.
Results: The WLC and PDD cohorts comprised 124 and 91 subjects, respectively. There were no significant differences in recurrence rates at 6 months (recurrence rate 9/123; 7.3%), 12 months (17/118; 14.4%), or 60 months (39/102; 38.2%), with odds ratios of 1.23 (0.48–3.25; P=0.64), 1.32 (0.67–2.62; P=0.42), and 1.12 (0.70–1.79; P=0.65), respectively. Further analysis showed no significant effect of PDD on recurrence by risk group or on mean recurrence-free survival (hazard ratio, 1.12; 0.70–1.79).
Conclusion: Photodynamic diagnosis with hexaminolevulinate did not reduce the recurrence of non-muscle invasive bladder carcinoma compared to standard white light cystoscopy when used for transurethral resection.
Figure 1
Figure 2