Background
The purpose of this study was to test the meaning of serum CRP, ESR, Platelet Count and Mean Platelet Volume ratio (PC/MPV) and plasma Fibrinogen in periprosthetic joint infection diagnosis.
Methods
Clinical data of 160 patients diagnosed with osteoarthritis (Group A), PJI (Group B) and aseptic loosening after joint arthroplasy (Group C) were retrospective studied. General data and preoperative serum CRP, ESR, Platelet count to Mean Platelet Volume ratio and plasma Fibrinogen level were recorded and compared.
Results
Serum CRP, ESR, PC/MPV and plasma Fibrinogen expression level in Group B are much higher than Group A and C. When PC/MPV>31.70 was set as the optimum threshold value for the diagnosis of PJI, the specificity of PC/MPV in PJI diagnosis was lower than CRP and ESR, whereas, the sensitivity of PC/MPV in PJI diagnosis was similar with CRP and ESR. When plasma Fibrinogen > 4.01 μg/mL was set as the optimum threshold value for the diagnosis of PJI, the specificity and sensitivity of plasma Fibrinogen in diagnosis of PJI was similar with CRP and ESR.
Conclusion
PC/MPV should not be used as the first screen marker for PJI diagnosis, whereas, the plasma Fibrinogen can be used as a new marker for PJI diagnosis.