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Research Article
Meysamreza Boghrati
Ahvaz Jundishapur University of Medical Sciences
Corresponding Author
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BackgroundEarly-onset sepsis is one of the most common causes of mortality in neonates. This studyaimed to determine the prevalence rate of nasopharyngeal colonization with commonbacterial agents causing early-onset neonatal sepsis and their relationship with blood cultureoutcomes in neonates.MethodAll neonates transferred to the neonatal intensive care unit were included in the study.Posterior pharynx secretions were swabbed and cultured. The isolated bacteria wereidentified by biochemical standard tests. Antibiotic Sensitivity Test was performed by thedisk diffusion method using Mueller-Hinton agar.ResultsThe pharyngeal specimens collected from 114 newborns were positive in 83 (72.8%) ofcases. Staphylococcus epidermidis was the most common bacterium. Twelve neonates hadpositive blood cultures. Concurrent positive blood and pharyngeal culture were reported in 8(7%) cases, which in 3 (37.5%) of them blood and pharyngeal cultures were similar.ConclusionStaphylococcus epidermidis accounted for 38.6% of bacteria cultured from pharyngeal swabsand 66.7% of bacteria cultured from blood samples, 37.5% of which were resistant toampicillin and 100% sensitive to vancomycin. One-hundred percent of E. coli cultures fromneonatal pharynges were resistant to ampicillin and about 50% of them were resistant togentamicin, cefotaxime, and ceftriaxone.
Keywords
newborn, nasopharyngeal culture, antibiotic resistance, Staphylococcus epidermidis, Escherichia coli
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Meysamreza Boghrati
Ahvaz Jundishapur University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 06 Feb, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
BackgroundEarly-onset sepsis is one of the most common causes of mortality in neonates. This studyaimed to determine the prevalence rate of nasopharyngeal colonization with commonbacterial agents causing early-onset neonatal sepsis and their relationship with blood cultureoutcomes in neonates.MethodAll neonates transferred to the neonatal intensive care unit were included in the study.Posterior pharynx secretions were swabbed and cultured. The isolated bacteria wereidentified by biochemical standard tests. Antibiotic Sensitivity Test was performed by thedisk diffusion method using Mueller-Hinton agar.ResultsThe pharyngeal specimens collected from 114 newborns were positive in 83 (72.8%) ofcases. Staphylococcus epidermidis was the most common bacterium. Twelve neonates hadpositive blood cultures. Concurrent positive blood and pharyngeal culture were reported in 8(7%) cases, which in 3 (37.5%) of them blood and pharyngeal cultures were similar.ConclusionStaphylococcus epidermidis accounted for 38.6% of bacteria cultured from pharyngeal swabsand 66.7% of bacteria cultured from blood samples, 37.5% of which were resistant toampicillin and 100% sensitive to vancomycin. One-hundred percent of E. coli cultures fromneonatal pharynges were resistant to ampicillin and about 50% of them were resistant togentamicin, cefotaxime, and ceftriaxone.
The full text of this article is available to read as a PDF.
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