A coupling coordination degree model and an interactive stress model of tourism economy and eco-environment in Pearl River Delta are established to analyze the dynamic coordinated relationship of 9 cities in Pearl River Delta from 2007 to 2018. Results show that in the time series, coupling coordination of the tourism economy and the eco-environment in 9 cities shows a steady upward trend; in the spatial pattern, the coupling coordination of coastal areas is generally better than non-coastal areas; dynamic coordinated relationship’s spatial distribution about the two systems exists in all cities in Pearl River Delta. Besides, according to the interactive stress model, there is a strong interactive stress between tourism economy and the eco-environment. And the level of tourism economy is higher in economically developed areas, and the possibility of deterioration of the eco-environment in economically backward areas is greater. With the interactive stress of the tourism economy and eco-environment, advice should be proposed to adjust the relationship between them, in order to coordinate smooth and optimized development.