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Research
Weikuan Gu
University of Tennessee Health Science Center College of Medicine Memphis
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1112-8088
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Patients with locally advanced colon cancer (LACC) treated with surgery had a high risk of local recurrence. The outcomes can vary significantly among patients with pT3 disease. This study was undertaken to assess whether low-energy electronic intraoperative radiotherapy (eIORT) can achieve promising results comparing with electron beam IORT (IOERT) and whether specific subgroups of patients with pT3 colon cancer may benefit from eIORT.
Methods
We retrospectively reviewed 44 patients with pT3 LACC treated with eIORT. Clinicopathologic characteristics were analyzed to identify patients that could potentially benefit from eIORT. Kaplan-Meier survival analysis was used to assess overall survival (OS) and progression free survival (PFS). The log-rank test was used for the subgroup comparison.
Results
The median follow-up of patients was 20.5 months (range, 6.1–38.8 months). At the time of analysis, 38 (86%) were alive and 6 (14%) had died of their disease. The 3-year Kaplan-Meier of PFS and OS for the entire cohort were 82.8% and 82.1%, respectively. At median follow-up, no in-field failure within the eIORT field had occurred. Locoregional and distant failure had occurred in 2 (5%) patients each. The rate of perioperative 30-day mortality was 0% and morbidity rate was 11%. Five patients experienced 7 complications, including 4 early complications (30-d) and three late complications (>30 days) leading early and late morbidity rates of 9% and 7%, respectively.
Conclusion
Low-energy eIORT can be considered as part of management in pT3 LACC.
Keywords
Low-energy electronic intraoperative radiotherapy, locally advanced colon cancer, pT3 colon cancer
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Weikuan Gu
University of Tennessee Health Science Center College of Medicine Memphis
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1112-8088
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 17 Feb, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Patients with locally advanced colon cancer (LACC) treated with surgery had a high risk of local recurrence. The outcomes can vary significantly among patients with pT3 disease. This study was undertaken to assess whether low-energy electronic intraoperative radiotherapy (eIORT) can achieve promising results comparing with electron beam IORT (IOERT) and whether specific subgroups of patients with pT3 colon cancer may benefit from eIORT.
Methods
We retrospectively reviewed 44 patients with pT3 LACC treated with eIORT. Clinicopathologic characteristics were analyzed to identify patients that could potentially benefit from eIORT. Kaplan-Meier survival analysis was used to assess overall survival (OS) and progression free survival (PFS). The log-rank test was used for the subgroup comparison.
Results
The median follow-up of patients was 20.5 months (range, 6.1–38.8 months). At the time of analysis, 38 (86%) were alive and 6 (14%) had died of their disease. The 3-year Kaplan-Meier of PFS and OS for the entire cohort were 82.8% and 82.1%, respectively. At median follow-up, no in-field failure within the eIORT field had occurred. Locoregional and distant failure had occurred in 2 (5%) patients each. The rate of perioperative 30-day mortality was 0% and morbidity rate was 11%. Five patients experienced 7 complications, including 4 early complications (30-d) and three late complications (>30 days) leading early and late morbidity rates of 9% and 7%, respectively.
Conclusion
Low-energy eIORT can be considered as part of management in pT3 LACC.
Figure 1
Figure 2
Figure 3
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