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Case report
Neuroendocrine carcinoma of the common bile duct associated with congenital bile duct dilatation: A case report
Yoshitaka Kiya
Tokyo Medical University: Tokyo Ika Daigaku
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1363-3838
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Cholangiocarcinoma is frequently seen in patients with congenital bile duct dilatation (CBD). Most cholangiocarcinomas are adenocarcinomas. Other types, especially neuroendocrine carcinomas (NECs), are rare. To the best of our knowledge, this is the third reported case of an NEC of the common bile duct associated with CBD and the first to receive adjuvant chemotherapy for advanced disease.
Case presentation
A 29-year-old woman presented with upper abdominal pain. Preoperative imaging indicated marked dilatation of the common bile duct and a tumor in the middle portion of the common bile duct. She was suspected of having distal cholangiocarcinoma associated with CBD and underwent pylorus-preserving pancreaticoduodenectomy. Pathological and immunohistological findings led to a final diagnosis of large-cell NEC (pT3aN1M0 pStageIIB). The postoperative course was uneventful, and she was administered cisplatin and irinotecan every 4 weeks (four cycles) as adjuvant chemotherapy. She has remained recurrence-free for 14 months.
Conclusion
This presentation is rare, and further reports are necessary.
Keywords
Neuroendocrine carcinoma, congenital bile duct dilatation, cholangiocarcinoma, large cell neuroendocrine carcinoma, adjuvant chemotherapy
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This is a preprint. It has not completed peer review.
Case report
Neuroendocrine carcinoma of the common bile duct associated with congenital bile duct dilatation: A case report
Yoshitaka Kiya
Tokyo Medical University: Tokyo Ika Daigaku
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1363-3838
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 08 Jan, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Cholangiocarcinoma is frequently seen in patients with congenital bile duct dilatation (CBD). Most cholangiocarcinomas are adenocarcinomas. Other types, especially neuroendocrine carcinomas (NECs), are rare. To the best of our knowledge, this is the third reported case of an NEC of the common bile duct associated with CBD and the first to receive adjuvant chemotherapy for advanced disease.
Case presentation
A 29-year-old woman presented with upper abdominal pain. Preoperative imaging indicated marked dilatation of the common bile duct and a tumor in the middle portion of the common bile duct. She was suspected of having distal cholangiocarcinoma associated with CBD and underwent pylorus-preserving pancreaticoduodenectomy. Pathological and immunohistological findings led to a final diagnosis of large-cell NEC (pT3aN1M0 pStageIIB). The postoperative course was uneventful, and she was administered cisplatin and irinotecan every 4 weeks (four cycles) as adjuvant chemotherapy. She has remained recurrence-free for 14 months.
Conclusion
This presentation is rare, and further reports are necessary.
Figure 1
Figure 2
Figure 3
Figure 4