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Research Article
Bang-dang Chen
Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
PCSK9 plays a pivotal role in lipid metabolism. The present study is to explore the potential novel single nucleotide polymorphisms (SNPs) of the PCSK9 gene which is associated with coronary artery disease (CAD) in the Han population who lived in Xinjiang, China. We conducted a case-control study and genotyped four tag SNPs of the PCSK9 gene in 950 CAD and 1082 health subjects in the Han population. This study showed that for rs2483205, the distributions in genotypes had significant differences between the CAD and control groups (p = 0.025), and the subjects with TT genotype had lower total cholesterol (TC) level than CT genotype (p = 0.025). For rs562556, there were significant differences between the CAD and control groups for distributions of genotypes (p = 0.020), and the individuals with a G allele had a lower low-density lipoprotein cholesterol (LDL-C) level than an A allele (p = 0.048). Furthermore, the TT genotype of rs2483205 and GG genotype of rs562556 were independently associated with CAD (odds ratio [OR] = 0.53, 95% confidence interval [CI] = 0.29-0.95, p = 0.032 and OR = 0.57, 95%CI = 0.34-0.95, p = 0.032, respectively). In conclusion, the rs2483205 and rs562556 were significantly associated with CAD.
Keywords
PCSK9, TT genotype, SNPs, lipid metabolism, CAD
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On 26 Feb, 2021
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Received 12 Feb, 2021
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On 03 Feb, 2021
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On 03 Feb, 2021
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On 02 Feb, 2021
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Bang-dang Chen
Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 22 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 01 Mar, 2021
Reviews received
Received 26 Feb, 2021
Reviewers agreed
On 26 Feb, 2021
Reviews received
Received 12 Feb, 2021
Reviewers agreed
On 03 Feb, 2021
Reviewers agreed
On 03 Feb, 2021
Reviewers agreed
On 02 Feb, 2021
Reviewers invited
Invitations sent on 02 Feb, 2021
Editor assigned
On 02 Feb, 2021
Editor invited
On 20 Jan, 2021
Submission checks complete
On 20 Jan, 2021
First submitted
On 05 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
PCSK9 plays a pivotal role in lipid metabolism. The present study is to explore the potential novel single nucleotide polymorphisms (SNPs) of the PCSK9 gene which is associated with coronary artery disease (CAD) in the Han population who lived in Xinjiang, China. We conducted a case-control study and genotyped four tag SNPs of the PCSK9 gene in 950 CAD and 1082 health subjects in the Han population. This study showed that for rs2483205, the distributions in genotypes had significant differences between the CAD and control groups (p = 0.025), and the subjects with TT genotype had lower total cholesterol (TC) level than CT genotype (p = 0.025). For rs562556, there were significant differences between the CAD and control groups for distributions of genotypes (p = 0.020), and the individuals with a G allele had a lower low-density lipoprotein cholesterol (LDL-C) level than an A allele (p = 0.048). Furthermore, the TT genotype of rs2483205 and GG genotype of rs562556 were independently associated with CAD (odds ratio [OR] = 0.53, 95% confidence interval [CI] = 0.29-0.95, p = 0.032 and OR = 0.57, 95%CI = 0.34-0.95, p = 0.032, respectively). In conclusion, the rs2483205 and rs562556 were significantly associated with CAD.
Figure 1
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