Significance of Detecting the Levels of miR-29a, Survivin and Igras in Patients With Lung Cancer and Tuberculosis
Background:When lung cancer is combined with tuberculosis at the same time, it is easy to be misdiagnosed and missed. The purpose of this article is to provide reference for patients with lung cancer complicated by active pulmonary tuberculosis.
Methods:The concentration of survivin in diseased tissue and miR-29a and IGRAs in serum in 25 patients with non-small-cell lung carcinoma (NSCLC) complicated by active pulmonary tuberculosis (APT) and 32 patients with NSCLC and 30 patients with APT were measured.
Results:The expressions of miR-29a in serum of the APT group were higher than those of the NSCLC complicated by APT group and the NSCLC group (p<0.05). The expressions of survivin in diseased tissue of the NSCLC complicated by APT group and the NSCLC group were higher than those of the APT group (p<0.05).The expression level of IGRAs in serum of the NSCLC complicated by APT group and the APT group was higher than those of the NSCLC group (p<0.05), the expression level of IGRAs in serum of the NSCLC complicated by APT group was higher than the APT group.
Conclusion:We should be on guard against patients with APT complicated by lung cancer, when miR-29a was low expression in serum and survivin was high expression in diseased tissue of the patient who was pathologically diagnosed with APT. We should be on the alert for patients with lung cancer complicated by APT, when miR-29a was high expression in serum and survivin was low expression in diseased tissue and IGRAs was high level in serum of the patient with lung cancer.
Posted 11 Jan, 2021
On 17 Jan, 2021
Received 16 Jan, 2021
On 15 Jan, 2021
On 14 Jan, 2021
Invitations sent on 04 Jan, 2021
On 03 Jan, 2021
On 03 Jan, 2021
On 03 Jan, 2021
On 03 Jan, 2021
Significance of Detecting the Levels of miR-29a, Survivin and Igras in Patients With Lung Cancer and Tuberculosis
Posted 11 Jan, 2021
On 17 Jan, 2021
Received 16 Jan, 2021
On 15 Jan, 2021
On 14 Jan, 2021
Invitations sent on 04 Jan, 2021
On 03 Jan, 2021
On 03 Jan, 2021
On 03 Jan, 2021
On 03 Jan, 2021
Background:When lung cancer is combined with tuberculosis at the same time, it is easy to be misdiagnosed and missed. The purpose of this article is to provide reference for patients with lung cancer complicated by active pulmonary tuberculosis.
Methods:The concentration of survivin in diseased tissue and miR-29a and IGRAs in serum in 25 patients with non-small-cell lung carcinoma (NSCLC) complicated by active pulmonary tuberculosis (APT) and 32 patients with NSCLC and 30 patients with APT were measured.
Results:The expressions of miR-29a in serum of the APT group were higher than those of the NSCLC complicated by APT group and the NSCLC group (p<0.05). The expressions of survivin in diseased tissue of the NSCLC complicated by APT group and the NSCLC group were higher than those of the APT group (p<0.05).The expression level of IGRAs in serum of the NSCLC complicated by APT group and the APT group was higher than those of the NSCLC group (p<0.05), the expression level of IGRAs in serum of the NSCLC complicated by APT group was higher than the APT group.
Conclusion:We should be on guard against patients with APT complicated by lung cancer, when miR-29a was low expression in serum and survivin was high expression in diseased tissue of the patient who was pathologically diagnosed with APT. We should be on the alert for patients with lung cancer complicated by APT, when miR-29a was high expression in serum and survivin was low expression in diseased tissue and IGRAs was high level in serum of the patient with lung cancer.