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Research Article
Dibyendu Pusti
University of Murcia
Corresponding Author
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The large incidence of myopia during the last decades is becoming a worldwide public health problem. Increasing myopia during childhood has been related to changing lifestyle and linked to larger eye growth, although the mechanism to explain how visual exposures affect ocular development is still unclear. The gene-environment interaction in myopia was investigated in a sample of 100 pairs of young twins with large prevalence of myopia. A classical twin’s study model was performed on objective refraction measured with an open-view peripheral wave-front sensor across a wide range of horizontal retinal eccentricities. In this sample, variance of refractive errors at the area surrounding the line of sight was mainly related to variance in shared-environmental exposures. From there, while moving towards the retinal periphery, the environmental influence over peripheral refractive error variance decreased gradually towards a genetically-driven model. In conclusion, environmental exposures, responsible of the increase in myopia incidence, seems to be affecting mainly the central area of the retinal in young myopes.
Keywords
myopia, refraction, environment
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
- SupplementaryTable1.Twincorrelationsacrosshorizontalretinaleccentricities.xlsx
Supplementary Table 1. Twin correlations across horizontal retinal eccentricities.
- SupplementaryTables2.SEMfittingsacrosshorizontalretinaleccentricities.xlsx
Supplementary Tables 2. SEM fittings across horizontal retinal eccentricities.
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CURRENT STATUS: Under Review
Version 1
Posted 20 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 03 Mar, 2021
Reviews received
Received 17 Feb, 2021
Reviewers agreed
On 01 Feb, 2021
Reviewers invited
Invitations sent on 01 Feb, 2021
Editor assigned
On 21 Jan, 2021
Editor invited
On 18 Jan, 2021
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On 18 Jan, 2021
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On 11 Jan, 2021
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A new preprint design is coming!
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Dibyendu Pusti
University of Murcia
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 20 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 03 Mar, 2021
Reviews received
Received 17 Feb, 2021
Reviewers agreed
On 01 Feb, 2021
Reviewers invited
Invitations sent on 01 Feb, 2021
Editor assigned
On 21 Jan, 2021
Editor invited
On 18 Jan, 2021
Submission checks complete
On 18 Jan, 2021
First submitted
On 11 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The large incidence of myopia during the last decades is becoming a worldwide public health problem. Increasing myopia during childhood has been related to changing lifestyle and linked to larger eye growth, although the mechanism to explain how visual exposures affect ocular development is still unclear. The gene-environment interaction in myopia was investigated in a sample of 100 pairs of young twins with large prevalence of myopia. A classical twin’s study model was performed on objective refraction measured with an open-view peripheral wave-front sensor across a wide range of horizontal retinal eccentricities. In this sample, variance of refractive errors at the area surrounding the line of sight was mainly related to variance in shared-environmental exposures. From there, while moving towards the retinal periphery, the environmental influence over peripheral refractive error variance decreased gradually towards a genetically-driven model. In conclusion, environmental exposures, responsible of the increase in myopia incidence, seems to be affecting mainly the central area of the retinal in young myopes.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
- SupplementaryTable1.Twincorrelationsacrosshorizontalretinaleccentricities.xlsx
Supplementary Table 1. Twin correlations across horizontal retinal eccentricities.
- SupplementaryTables2.SEMfittingsacrosshorizontalretinaleccentricities.xlsx
Supplementary Tables 2. SEM fittings across horizontal retinal eccentricities.
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