Protective Effect of Royal Jelly against Hepatorenal toxicity induced by Deltamethrin in Male Albino Rats: Biochemical, Histopathological studies

DOI: https://doi.org/10.21203/rs.3.rs-1454007/v1

Abstract

One of the most environmental and industrial pollutants that are toxic to humans, animals, fishes,

and birds. The most common sources of human and animal exposure to deltamethrin (DM) are 

polluted water and food. This study was done to evaluate the nephrohepatic toxicity of 

deltamethrin. Twenty-four female rats were used. The first group used as control. The second

and third groups givens deltamethrin orally in dose of 1/10 % of the LD50 equal to 0.6mg\kg bw

alone and plus Royal Jelly (RJ) at dose of 100 mg/kg/day for two month, respectively. Oral 

administration of DM induced biochemical and histopathological alterations. DM toxicity 

exhibited changes in the liver and kidney function tests manifested by increase AST, ALT, urea, 

uric acid, and creatinine with no changes were noticed in plasma proteins when compared to 

control group. Giving RJ ameliorated the hepatorenal toxicity by causing recovery in both liver 

and kidney functions in comparison to DM given group. Pathologically, severe degenerative and 

necrotic changes in livers and kidneys showed in deltamethrin group, where it improved to 

moderate to mild lesions by protective royal gel substance. This study concluded that royal gel 

substance has been shown benefit in lower down the side effects and increasing the rate of 

improvement of injury induced by of Deltamethrin.

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Declarations

Competing interests: The authors declare no competing interests.