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Research Article
Hiroyuki Suzuki
Wakayama Medical University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Coronary artery aneurysm (CAA) is an important complication of Kawasaki disease (KD) that is associated with arterial structure damage. However, few studies have examined structural changes in coronary arteries not associated with CAA.
Methods
We examined coronary arteries in KD patients with CAAs who underwent follow-up coronary angiography (CAG) and optical coherence tomography (OCT). Coronary arterial branches with no abnormal findings on most recent CAG were classified into two groups. Arteries with an acute-phase CAA that later regressed were classified as group R and arteries with no abnormal findings on either acute or convalescent phase CAG were classified as group N. Coronary arterial wall structural changes were compared between groups using OCT.
Results
Fifty-seven coronary arterial branches in 23 patients were evaluated by OCT. Thirty-six branches showed no abnormality on most recent CAG. Both groups R and N comprised 18 branches. Maximum intimal thickness in groups R and N was 475 and 355 µm, respectively (p = 0.007). The incidence of disruption of the media was 100% and 67%, respectively (p = 0.02). Calcification, macrophage accumulation, and thrombus were not found in either group.
Conclusions
Intimal thickening and disruption of the media occur not only in coronary arteries with acute phase CAAs that later regress in the convalescent phase, but also in arteries with normal CAG findings in the acute and convalescent phases.
Keywords
Kawasaki disease, wall structure, coronary artery, intimal thickness, optical coherence tomography (OCT)
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Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 18 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 15 Apr, 2021
Reviews received
Received 31 Mar, 2021
Reviewers agreed
On 24 Mar, 2021
Reviews received
Received 04 Mar, 2021
Reviewers agreed
On 20 Feb, 2021
Reviewers invited
Invitations sent on 24 Jan, 2021
Editor assigned
On 24 Jan, 2021
Editor invited
On 15 Jan, 2021
Submission checks complete
On 15 Jan, 2021
First submitted
On 12 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at BMC Cardiovascular Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Hiroyuki Suzuki
Wakayama Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 18 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 15 Apr, 2021
Reviews received
Received 31 Mar, 2021
Reviewers agreed
On 24 Mar, 2021
Reviews received
Received 04 Mar, 2021
Reviewers agreed
On 20 Feb, 2021
Reviewers invited
Invitations sent on 24 Jan, 2021
Editor assigned
On 24 Jan, 2021
Editor invited
On 15 Jan, 2021
Submission checks complete
On 15 Jan, 2021
First submitted
On 12 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Coronary artery aneurysm (CAA) is an important complication of Kawasaki disease (KD) that is associated with arterial structure damage. However, few studies have examined structural changes in coronary arteries not associated with CAA.
Methods
We examined coronary arteries in KD patients with CAAs who underwent follow-up coronary angiography (CAG) and optical coherence tomography (OCT). Coronary arterial branches with no abnormal findings on most recent CAG were classified into two groups. Arteries with an acute-phase CAA that later regressed were classified as group R and arteries with no abnormal findings on either acute or convalescent phase CAG were classified as group N. Coronary arterial wall structural changes were compared between groups using OCT.
Results
Fifty-seven coronary arterial branches in 23 patients were evaluated by OCT. Thirty-six branches showed no abnormality on most recent CAG. Both groups R and N comprised 18 branches. Maximum intimal thickness in groups R and N was 475 and 355 µm, respectively (p = 0.007). The incidence of disruption of the media was 100% and 67%, respectively (p = 0.02). Calcification, macrophage accumulation, and thrombus were not found in either group.
Conclusions
Intimal thickening and disruption of the media occur not only in coronary arteries with acute phase CAAs that later regress in the convalescent phase, but also in arteries with normal CAG findings in the acute and convalescent phases.
Figure 1
Figure 2
Figure 3
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