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Research
wenlong xiu
Fujian Province Hospital for Women and Children: Fujian Provincial Maternity and Children's Hospital
Corresponding Author
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Background
Oropharyngeal administration of colostrum (OAC) may provide immunoprotective and anti-inflammatory effects that potentially reduce the incidence of necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) and improve short-term outcomes.
Objective
To evaluate the role of OAC in the early prevention of NEC and LOS in preterm infants with gestational age (GA) ≤ 32 weeks.
Methods
A randomized, placebo-controlled trial was conducted in a 40-bed tertiary neonatal intensive care unit (NICU) in China. Preterm infants with GA ≤ 32 weeks were divided randomly into an OAC group, which received 0.4 ml maternal colostrum smearing via the oropharyngeal route every 3 hours for 10 days beginning within the first 48 hours after birth, and a control group, which received normal saline instead. Data from the two groups were collected and compared.
Results
A total of 127 patients in the OAC group and 125 patients in the control group were finally enrolled. The incidence of NEC (Bell stage 2 or 3) and LOS was lower in the OAC group [2.4% vs. 10.4%, χ2 = 6.845, ༰=0.009; 4.7% vs. 13.6%, χ2 = 5.983, ༰=0.014]. In addition, the incidence of intraventricular hemorrhage (IVH) (stage 3 or 4) was lower [1.6% vs. 7.2%,χ2 = 4.775, ༰=0.029], and the time of achieving full enteral feeding was shorter [ 22.0 days vs. 25.0 days༌Z = 6༌424.500༌P = 0.009)] in the OAC group. No cases of adverse reactions were observed in either group.
Conclusions
OAC is a safe and simple NICU procedure that yields a potential advantage in decreasing the incidence of NEC, LOS, and severe IVH and shortening the time to achieve full enteral feeding in preterm infants with GA ≤ 32 weeks.
Trial registration
Chinese Clinical Trial Registry, ChiCTR1900023697, Registered 8 June 2019, Retrospectively registered, http://www.chictr.org.cn/edit.aspx? pid = 39398
Keywords
oropharyngeal administration of colostrum, infant, preterm, necrotizing enterocolitis, late-onset sepsis
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CURRENT STATUS: Published
View the published article at International Breastfeeding Journal.
Version 1
Posted 15 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 06 Mar, 2021
Review #3 received
Received 04 Mar, 2021
Review #2 received
Received 04 Mar, 2021
Reviewer #3 agreed
On 18 Feb, 2021
Review #1 received
Received 19 Jan, 2021
Reviewer #2 agreed
On 18 Jan, 2021
Reviewers invited
Invitations sent on 18 Jan, 2021
Reviewer #1 agreed
On 18 Jan, 2021
Editor assigned
On 09 Jan, 2021
Submission checks complete
On 09 Jan, 2021
Editor invited
On 09 Jan, 2021
First submitted
On 08 Jan, 2021
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Subject Areas
Sexual & Reproductive Medicine
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at International Breastfeeding Journal.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
wenlong xiu
Fujian Province Hospital for Women and Children: Fujian Provincial Maternity and Children's Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at International Breastfeeding Journal.
Version 1
Posted 15 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 06 Mar, 2021
Review #3 received
Received 04 Mar, 2021
Review #2 received
Received 04 Mar, 2021
Reviewer #3 agreed
On 18 Feb, 2021
Review #1 received
Received 19 Jan, 2021
Reviewer #2 agreed
On 18 Jan, 2021
Reviewers invited
Invitations sent on 18 Jan, 2021
Reviewer #1 agreed
On 18 Jan, 2021
Editor assigned
On 09 Jan, 2021
Submission checks complete
On 09 Jan, 2021
Editor invited
On 09 Jan, 2021
First submitted
On 08 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Sexual & Reproductive Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at International Breastfeeding Journal.
Background
Oropharyngeal administration of colostrum (OAC) may provide immunoprotective and anti-inflammatory effects that potentially reduce the incidence of necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) and improve short-term outcomes.
Objective
To evaluate the role of OAC in the early prevention of NEC and LOS in preterm infants with gestational age (GA) ≤ 32 weeks.
Methods
A randomized, placebo-controlled trial was conducted in a 40-bed tertiary neonatal intensive care unit (NICU) in China. Preterm infants with GA ≤ 32 weeks were divided randomly into an OAC group, which received 0.4 ml maternal colostrum smearing via the oropharyngeal route every 3 hours for 10 days beginning within the first 48 hours after birth, and a control group, which received normal saline instead. Data from the two groups were collected and compared.
Results
A total of 127 patients in the OAC group and 125 patients in the control group were finally enrolled. The incidence of NEC (Bell stage 2 or 3) and LOS was lower in the OAC group [2.4% vs. 10.4%, χ2 = 6.845, ༰=0.009; 4.7% vs. 13.6%, χ2 = 5.983, ༰=0.014]. In addition, the incidence of intraventricular hemorrhage (IVH) (stage 3 or 4) was lower [1.6% vs. 7.2%,χ2 = 4.775, ༰=0.029], and the time of achieving full enteral feeding was shorter [ 22.0 days vs. 25.0 days༌Z = 6༌424.500༌P = 0.009)] in the OAC group. No cases of adverse reactions were observed in either group.
Conclusions
OAC is a safe and simple NICU procedure that yields a potential advantage in decreasing the incidence of NEC, LOS, and severe IVH and shortening the time to achieve full enteral feeding in preterm infants with GA ≤ 32 weeks.
Trial registration
Chinese Clinical Trial Registry, ChiCTR1900023697, Registered 8 June 2019, Retrospectively registered, http://www.chictr.org.cn/edit.aspx? pid = 39398
Figure 1
Figure 2
Figure 3
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