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Article
Joshua Dudman
HHMI, Janelia Research Campus
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4436-1057
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The hippocampus encodes both spatial and non-spatial features of an environment thought to be critical to guide navigational trajectories and associative learning, respectively. These seemingly dichotomous roles have been reconciled in a proposed cognitive map - a representation of environment structure abstracted away from specific behavioral demands. However, the extent to which a cognitive map is independent of behavioral demands remains unclear because direct comparisons across environments with common structure but different spatial/behavioral context is lacking. Here we compare behaviors in mice trained to navigate to a hidden target in a physical arena and manipulate a joystick to a virtual target to collect a delayed reward. Comparison of behaviors with an artificial agent revealed a common algorithmic basis for learned foraging trajectories in both contexts. Imaging CA1 neural activity revealed a similar map-like encoding of active foraging; however, detailed analysis of ensemble activity, optogenetic inactivation, and modeling revealed a context-specific functional dissociation. In a navigational context, CA1 was critical for retrospective evaluation of spatial trajectories, but dispensable for initiation. In a non-navigational context, CA1 activity was critical for initiation and planning foraging trajectories. This work highlights how construction of a cognitive map to facilitate idiosyncratic behavioral demands7 is critical for foraging in diverse spatial contexts.
Keywords
hippocampal cognitive map, hippocampus, spatial context
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- JiangDudmanMovieS1.mov
Supplementary Video 1: STF task recorded with 2 cameras to illustrate real-time tracking performance.
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This preprint is under consideration at a Nature Portfolio Journal. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Article
Joshua Dudman
HHMI, Janelia Research Campus
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4436-1057
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 29 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The hippocampus encodes both spatial and non-spatial features of an environment thought to be critical to guide navigational trajectories and associative learning, respectively. These seemingly dichotomous roles have been reconciled in a proposed cognitive map - a representation of environment structure abstracted away from specific behavioral demands. However, the extent to which a cognitive map is independent of behavioral demands remains unclear because direct comparisons across environments with common structure but different spatial/behavioral context is lacking. Here we compare behaviors in mice trained to navigate to a hidden target in a physical arena and manipulate a joystick to a virtual target to collect a delayed reward. Comparison of behaviors with an artificial agent revealed a common algorithmic basis for learned foraging trajectories in both contexts. Imaging CA1 neural activity revealed a similar map-like encoding of active foraging; however, detailed analysis of ensemble activity, optogenetic inactivation, and modeling revealed a context-specific functional dissociation. In a navigational context, CA1 was critical for retrospective evaluation of spatial trajectories, but dispensable for initiation. In a non-navigational context, CA1 activity was critical for initiation and planning foraging trajectories. This work highlights how construction of a cognitive map to facilitate idiosyncratic behavioral demands7 is critical for foraging in diverse spatial contexts.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
The full text of this article is available to read as a PDF.
There is NO Competing Interest.
This is a list of supplementary files associated with this preprint. Click to download.
- JiangDudmanMovieS1.mov
Supplementary Video 1: STF task recorded with 2 cameras to illustrate real-time tracking performance.
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