See the published version of this preprint at Lipids in Health and Disease.
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Wenbin Zhang
Zhejiang University School of Medicine Sir Run Run Shaw Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4746-9570
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Atherosclerosis is associated with chronic inflammation and lipid metabolism. The neutrophil to lymphocyte ratio (NLR) as an indicator of inflammation has been confirmed to be associated with cardiovascular disease prognosis. However, few studies have explored the effects of blood lipid variability on NLR. The aim of this study was to explore the relationship between variability in blood lipid levels and NLR.
Methods: The association between variability in blood lipids and NLR was assessed with both univariate and multivariate linear regression. Multivariate linear regression was also performed for a subgroup analysis.
Results: The variability of high-density lipoprotein cholesterol (HDL-C) (regression coefficients [β] 4.008, standard error (SE) 0.503, P-value<0.001) and low-density lipoprotein cholesterol (LDL-C) ([β] 0.626, SE 0.164, P-value<0.001) were risk factors for the NLR value, although baseline LDL-C and HDL-C were not risk factors for NLR values. Variability of HDL-C ([β] 4.328, SE 0.578, P-value<0.001) and LDL-C ([β] 0.660, SE 0.183, P-value<0.001) were risk factors for NLR variability. Subgroup analysis demonstrated that the relationship between variability of LDL-C and NLR was consistent with the trend of the total sample for those with diabetes mellitus, controlled blood lipid, statins, atorvastatin. The relationship between the variability of HDL-C and NLR was consistent with the trend of the total sample in all subgroups.
Conclusion: The variability of HDL-C and LDL-C are risk factors for the value and variability of NLR, while the relationship between variability of HDL-C and NLR is more stable than the variability of LDL-C in the subgroup analysis, which provides a new perspective for controlling inflammation in patients undergoing PCI.
Keywords
Variability, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, neutrophil to lymphocyte ratio, percutaneous coronary intervention, atherosclerosis
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CURRENT STATUS: Published
View the published article at Lipids in Health and Disease.
Version 2
Posted 18 May, 2020
No community comments so far
Editorial decision: Accept
On 12 May, 2020
Review #2 received
Received 09 May, 2020
Review #1 received
Received 09 May, 2020
Editor assigned
On 05 May, 2020
Reviewers invited
Invitations sent on 05 May, 2020
Reviewer #1 agreed
On 05 May, 2020
Reviewer #2 agreed
On 05 May, 2020
Submission checks complete
On 04 May, 2020
Editor invited
On 04 May, 2020
No comments provided
Editorial decision: Major revision
On 14 Apr, 2020
Review #3 received
Received 09 Apr, 2020
Review #2 received
Received 08 Apr, 2020
Review #1 received
Received 06 Apr, 2020
Reviewer #3 agreed
On 31 Mar, 2020
Reviewer #1 agreed
On 26 Mar, 2020
Reviewer #2 agreed
On 26 Mar, 2020
Reviewers invited
Invitations sent on 26 Mar, 2020
Editor assigned
On 18 Feb, 2020
First submitted
On 17 Feb, 2020
Submission checks complete
On 17 Feb, 2020
Editor invited
On 17 Feb, 2020
Metrics
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See the published version of this preprint at Lipids in Health and Disease.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Wenbin Zhang
Zhejiang University School of Medicine Sir Run Run Shaw Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4746-9570
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Lipids in Health and Disease.
Version 2
Posted 18 May, 2020
No community comments so far
Editorial decision: Accept
On 12 May, 2020
Review #2 received
Received 09 May, 2020
Review #1 received
Received 09 May, 2020
Editor assigned
On 05 May, 2020
Reviewers invited
Invitations sent on 05 May, 2020
Reviewer #1 agreed
On 05 May, 2020
Reviewer #2 agreed
On 05 May, 2020
Submission checks complete
On 04 May, 2020
Editor invited
On 04 May, 2020
No comments provided
Editorial decision: Major revision
On 14 Apr, 2020
Review #3 received
Received 09 Apr, 2020
Review #2 received
Received 08 Apr, 2020
Review #1 received
Received 06 Apr, 2020
Reviewer #3 agreed
On 31 Mar, 2020
Reviewer #1 agreed
On 26 Mar, 2020
Reviewer #2 agreed
On 26 Mar, 2020
Reviewers invited
Invitations sent on 26 Mar, 2020
Editor assigned
On 18 Feb, 2020
First submitted
On 17 Feb, 2020
Submission checks complete
On 17 Feb, 2020
Editor invited
On 17 Feb, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Lipids in Health and Disease.
Background: Atherosclerosis is associated with chronic inflammation and lipid metabolism. The neutrophil to lymphocyte ratio (NLR) as an indicator of inflammation has been confirmed to be associated with cardiovascular disease prognosis. However, few studies have explored the effects of blood lipid variability on NLR. The aim of this study was to explore the relationship between variability in blood lipid levels and NLR.
Methods: The association between variability in blood lipids and NLR was assessed with both univariate and multivariate linear regression. Multivariate linear regression was also performed for a subgroup analysis.
Results: The variability of high-density lipoprotein cholesterol (HDL-C) (regression coefficients [β] 4.008, standard error (SE) 0.503, P-value<0.001) and low-density lipoprotein cholesterol (LDL-C) ([β] 0.626, SE 0.164, P-value<0.001) were risk factors for the NLR value, although baseline LDL-C and HDL-C were not risk factors for NLR values. Variability of HDL-C ([β] 4.328, SE 0.578, P-value<0.001) and LDL-C ([β] 0.660, SE 0.183, P-value<0.001) were risk factors for NLR variability. Subgroup analysis demonstrated that the relationship between variability of LDL-C and NLR was consistent with the trend of the total sample for those with diabetes mellitus, controlled blood lipid, statins, atorvastatin. The relationship between the variability of HDL-C and NLR was consistent with the trend of the total sample in all subgroups.
Conclusion: The variability of HDL-C and LDL-C are risk factors for the value and variability of NLR, while the relationship between variability of HDL-C and NLR is more stable than the variability of LDL-C in the subgroup analysis, which provides a new perspective for controlling inflammation in patients undergoing PCI.
Figure 1
Figure 2
Figure 3
Figure 4
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