DOI: https://doi.org/10.21203/rs.3.rs-1464316/v1
Background: Totally extraperitoneal(TEP) inguinal hernia repair is a minimally invasive procedure. Mesh infection is one of the challenging complications after TEP inguinal hernia repair. However, the cases of delayed asymptomatic mesh infection caused by hernia mesh is extremely rare. This report aims to reveal that the risk of mesh infection may occur after a long period of this surgery. This report is also intended to suggest surgeons pay more attention to the follow-up of such patients and to be aware of the possibility of asymptomatic mesh infection to assist in early diagnosis and treatment.
Case presentation: A 63-year-old male patient, who underwent TEP inguinal hernia repair 6 years ago for right inguinal hernia, fell down accidentally 2 weeks ago. Enhanced computed tomography(CT) showed lower right abdomen space-occupying lesions. So he underwent laparoscopic surgery during which abscess caused by delayed mesh infection was found. After removing the mesh and abscess, he was discharged.
Conclusion: The risk of mesh infection after TEP inguinal hernia repair is low, but it can last for more than 6 years and can even be asymptomatic as long as the mesh remains in the body.
TEP inguinal hernia repair is a minimally invasive procedure that has become more widely applied in the last twenty years, with approximately 20 million herniorrhaphy procedures performed worldwide each year. With the wide application of this procedure[1], complications related to mesh have become increasingly prominent, and mesh infection is one of the challenging complications after surgery. However, a review of articles about mesh infection from 1970 to 2021 revealed only a few case reports, and no other studies on asymptomatic mesh infection were found. The case in this study is very rare. Delayed asymptomatic mesh infection was found in a patient who underwent TEP inguinal hernia repair 6 years prior. Then, a successful procedure was performed to remove the mesh and abscess.
The patient in this study signed informed consent regarding publishing their data and photographs. The patient was a 63-year-old male with no history of smoking or diabetes. He accidentally fell down 2 weeks prior to admission and hurt his hip. CT results showed space-occupying lesions in the lower right abdomen. He underwent TEP inguinal hernia repair 6 years ago for a right inguinal hernia in our hospital. The surgery went smoothly. During that surgery, hydrophilic anatomical mesh (15 cm×10 cm), made of three-dimensional polyester composite silk, was used to reinforce the cavity wall. No recurrence of inguinal hernia or seroma was found one month later. When the patient was admitted to our hospital this time, there was no fever, redness, purulent drainage or abdominal discomfort except for a low ALB level (35.8 g/L, normal range 40-55 g/L). Other blood test results were within normal ranges. A contrast-enhanced CT scan showed a 4.02 cm×10.57 cm×5.80 cm cystic low-density image beside the cecum of the right lower abdomen and the right side of the pelvis (Fig. 1). Contrast-enhanced MRI also showed a cystic abnormal signal shadow in the right lower ventral-pelvic cavity; however, its relation to the anterior abdominal wall has yet to be identified.
Treatment through surgery
Cystic space-occupying lesions were found in the abdominal cavity before surgery, so laparoscopy was performed. A round mass outside the peritoneum in the right inguinal area was seen during the operation (Fig. 2), but it was not adhered to the appendix, cecum or other organs. After cutting the peritoneum along the edge of the mass, gray–white pus was overflowing. The mesh was wrapped by the wall of the abscess and adhered to the blood vessel of the right spermatic cord (Fig. 3). The abscess wall and the mesh were removed (Fig. 4). The peritoneum was sutured, and a drainage tube was placed on the wound outside the peritoneum. No specific pathogenic microorganisms were found in the mesh or pus, and no obvious complications were seen in this patient when discharged from our hospital. In addition, no sign of hernia recurrence was seen after the operation, and no abnormality was found by CT scan after 1 month.
Compared with open hernia repair, TEP inguinal hernia repair is associated with a lower risk of mesh infection. The reported occurrence of mesh infection is 0.7%-2% [2, 3]. Delayed mesh infection generally refers to infection after 2 months. In some cases, the risk can persist for several months or years. However, the occurrence of delayed mesh infection is very low [4]. Most delayed mesh infections can be easily diagnosed according to the clinical manifestations, which are inflammatory response for several months to several years after mesh placement, pus accumulation in local areas, ulceration, sinus formation, and even mesh exposure. In this case, the delayed mesh infection was asymptomatic and found by chance. Therefore, delayed mesh infection was difficult to diagnose at the early stage, as few cases have been reported.
In this case, infection was controlled after removal of the mesh, and follow-up showed no secondary infection of the incision or hernia recurrence. Theoretically, removal of the mesh could lead to recurrence of the hernia. However, when we removed the mesh, we found dense scarring beneath it. The biological nature of the mesh causes infiltration into fibrous tissues in local areas, which leads to scarring. This is why no recurrence of inguinal hernia was found during postoperative follow-up. Fawole et al. [5] also found that the recurrence rate of delayed mesh infection after mesh removal was less than 5%.
To the best of our knowledge, this is the only case of asymptomatic mesh infection associated with inguinal hernia repair six years after the first repair. This case reveals that although infection from TEP inguinal hernia repair mesh is rare, the risk can persist for as long as the mesh remains in the patient. The cause of delayed mesh infection has yet to be identified and may be related to patient differences. However, further study is needed. Our study is also intended to raise the awareness of doctors to pay more attention to the follow-up and be aware of the possibility of mesh infection in patients undergoing inguinal hernia repair with mesh insertion to help diagnosis and treatment at the early stage.
Ethics approval and consent to participate
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Since no human experimentation was performed, no approval by an ethics board was required.
Consent for publication
The patient has consented to the submission of the case report to the journal. Informed consent was obtained from the patient for publication.
Availability of data and materials
All data and material are included in this published article.
Competing interests
The authors declare that they have no competing interests.
Funding
Not applicable.
Authors' contributions
Zhiwang Li and En Li wrote the main manuscript text. En Li and Haijing Zeng and Zhiwang Li participated in the operation. Yuping Liu and Zuguang Wu prepared figures 1-4. All authors read and approved the final manuscript.
Acknowledgements
Not applicable.