This preprint is under consideration at a Nature Portfolio Journal. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Nature journals have partnered with Research Square to offer In Review, a journal-integrated preprint deposition service.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Article
Palwende Boua
Clinical Research Unit of Nanoro , Institut de Recherche en Sciences de la Santé
Corresponding Author
ORCiD: https://orcid.org/0000-0001-8325-2665
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Atherosclerosis precedes the onset of many clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men) aged 40 to 60 years resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci, SIRPA (p=4.7E-08), and FBXL17 (p=2.5E-08), were identified in the combined dataset. Sex-stratified analysis revealed associations with two male-specific loci, SNX29 (p=6.3E-09) and MAP3K7 (p=5.3E-08), and two female-specific loci, LARP6 (p=2.4E-09) and PROK1 (p=1.0E-08). Regional associations were replicated with known risk loci for atherosclerosis and CVDs with different lead SNPs than in Europeans and significant enrichment for oestrogen response genes for female-specific signals were identified. The genes identified showed biological relevance to atherosclerosis and/or CVDs, as well as sex-differences and transferability of signals from non-African studies.
Keywords
Atherosclerosis, cardiovascular diseases, carotid intima-media thickness
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
There is NO Competing Interest.
This is a list of supplementary files associated with this preprint. Click to download.
- BouaGWAScIMTSuppTextFigures.pdf
Supplementary Material
- SuppTable123.xlsx
Supp Table 1, Supp Table 2, Supp Table 3
- SuppTable4aFunctionalAnnotationAll.xlsx
Supp_Table_4a
- SuppTable4bFunctionalAnnotationFemale.xlsx
Supp_Table_4b
- SuppTable4cFunctionalAnnotationMale.xlsx
Supp_Table_4c
- SuppTable5aGeneMapAll.xlsx
Supp_Table_5a
- SuppTable5bGeneMapFemale.xlsx
Supp_Table_5b
- SuppTable5cGeneMapMale.xlsx
Supp_Table_5c
- SuppTable6aGeneSetAll.xlsx
Supp_Table_6a
- SuppTable6bGeneSetFemale.xlsx
Supp_Table_6b
- SuppTable6cGeneSetMale.xlsx
Supp_Table_6c
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 22 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at a Nature Portfolio Journal. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Nature journals have partnered with Research Square to offer In Review, a journal-integrated preprint deposition service.
Article
Palwende Boua
Clinical Research Unit of Nanoro , Institut de Recherche en Sciences de la Santé
Corresponding Author
ORCiD: https://orcid.org/0000-0001-8325-2665
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 22 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Atherosclerosis precedes the onset of many clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men) aged 40 to 60 years resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci, SIRPA (p=4.7E-08), and FBXL17 (p=2.5E-08), were identified in the combined dataset. Sex-stratified analysis revealed associations with two male-specific loci, SNX29 (p=6.3E-09) and MAP3K7 (p=5.3E-08), and two female-specific loci, LARP6 (p=2.4E-09) and PROK1 (p=1.0E-08). Regional associations were replicated with known risk loci for atherosclerosis and CVDs with different lead SNPs than in Europeans and significant enrichment for oestrogen response genes for female-specific signals were identified. The genes identified showed biological relevance to atherosclerosis and/or CVDs, as well as sex-differences and transferability of signals from non-African studies.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
There is NO Competing Interest.
This is a list of supplementary files associated with this preprint. Click to download.
- BouaGWAScIMTSuppTextFigures.pdf
Supplementary Material
- SuppTable123.xlsx
Supp Table 1, Supp Table 2, Supp Table 3
- SuppTable4aFunctionalAnnotationAll.xlsx
Supp_Table_4a
- SuppTable4bFunctionalAnnotationFemale.xlsx
Supp_Table_4b
- SuppTable4cFunctionalAnnotationMale.xlsx
Supp_Table_4c
- SuppTable5aGeneMapAll.xlsx
Supp_Table_5a
- SuppTable5bGeneMapFemale.xlsx
Supp_Table_5b
- SuppTable5cGeneMapMale.xlsx
Supp_Table_5c
- SuppTable6aGeneSetAll.xlsx
Supp_Table_6a
- SuppTable6bGeneSetFemale.xlsx
Supp_Table_6b
- SuppTable6cGeneSetMale.xlsx
Supp_Table_6c
Loading...