The main objective of this study is to explore determinants that influence women entrepreneurs’ performance in medium and small enterprises in case of Gondar city in Ethiopia. The study employed a binary logistic regression model to identify determinants that influence women entrepreneurs’ performance. The binary logistic regression results show that educational level, working experience, access to finance, access to business training, government support, access to information, land ownership and reasonable levied tax are statistically significant predictors of performance in the study area. It is clear that in the context of Ethiopia, the determinants that influence women entrepreneurs’ performance could be aligned to these variables.