The current study was aimed to assess the association between liver enzymes and blood lipid profile in a sample of Yemeni patients with T2D. This is a case-control study comprising 142 T2D patients and 142 healthy control subjects at the Ibn-Sina hospital's outpatient clinics in Mukalla, Yemen. Fasting blood glucose (FBG), total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-cholesterol), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) were determined using Cobas Integra Plus 400 autoanalyzer. Also, anthropometric and blood pressure measurements were taken from each participant. Independent sample T-test and Pearson correlation coefficient were used. T2D patients had significantly higher FBG (P= <0.0001), total cholesterol (P= <0.0001), LDL-cholesterol (P= <0.0001), and GGT (P= <0.0001) while, HDL-cholesterol was significantly lower in T2D patients (P= 0.021). In correlation analysis, serum GGT was positively associated with FBG (r= 0.216; P= <0.0001), total cholesterol (r= 0.196; P= 0.0001), triglyceride (r= 0.123; P= 0.038), and LDL-cholesterol (r= 0.209; P= <0.0001). Also, serum ALT was positively associated with FBG (r= 0.145, P= 0.014) and triglyceride (r= 0.172, P= 0.004). We conclude that higher ALT and GGT are used as the predictive biomarkers for NAFLD in T2D patients with hyperlipidemia. Therefore, routine screening of liver enzymes and lipid profile in T2D patients is recommended to detect liver abnormalities and diminish diabetes complications.
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Posted 15 Mar, 2021
Posted 15 Mar, 2021
The current study was aimed to assess the association between liver enzymes and blood lipid profile in a sample of Yemeni patients with T2D. This is a case-control study comprising 142 T2D patients and 142 healthy control subjects at the Ibn-Sina hospital's outpatient clinics in Mukalla, Yemen. Fasting blood glucose (FBG), total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-cholesterol), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) were determined using Cobas Integra Plus 400 autoanalyzer. Also, anthropometric and blood pressure measurements were taken from each participant. Independent sample T-test and Pearson correlation coefficient were used. T2D patients had significantly higher FBG (P= <0.0001), total cholesterol (P= <0.0001), LDL-cholesterol (P= <0.0001), and GGT (P= <0.0001) while, HDL-cholesterol was significantly lower in T2D patients (P= 0.021). In correlation analysis, serum GGT was positively associated with FBG (r= 0.216; P= <0.0001), total cholesterol (r= 0.196; P= 0.0001), triglyceride (r= 0.123; P= 0.038), and LDL-cholesterol (r= 0.209; P= <0.0001). Also, serum ALT was positively associated with FBG (r= 0.145, P= 0.014) and triglyceride (r= 0.172, P= 0.004). We conclude that higher ALT and GGT are used as the predictive biomarkers for NAFLD in T2D patients with hyperlipidemia. Therefore, routine screening of liver enzymes and lipid profile in T2D patients is recommended to detect liver abnormalities and diminish diabetes complications.
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