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Research Article
Lotfi S. Bin Dahman
College of Medicine and Health Sciences, Hadhramout University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1526-4955
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Declarations:
Declarations
- This study involved human subjects.
- The author confirmed that all appropriate ethical guidelines for the use of human subjects have been followed, any necessary IRB and/or ethics committee review has been obtained, and information about the IRB/ethics committee is included in the manuscript.
- The author has confirmed that all necessary patient/participant consent or assent has been obtained and the appropriate institutional forms have been archived. If the IRB/ethics committee waived the requirement for patient/participant consent or assent, an explanation for the waiver is included in the text.
- This study involved the use of non-human vertebrates.
- The author has confirmed that all appropriate ethical guidelines for the handling and use of animals in research have been followed and details of the oversight board have been included in the text.
- The author has confirmed that a statement listing potential conflicts of interest or lack thereof is included in the text.
The current study was aimed to assess the association between liver enzymes and blood lipid profile in a sample of Yemeni patients with T2D. This is a case-control study comprising 142 T2D patients and 142 healthy control subjects at the Ibn-Sina hospital's outpatient clinics in Mukalla, Yemen. Fasting blood glucose (FBG), total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-cholesterol), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) were determined using Cobas Integra Plus 400 autoanalyzer. Also, anthropometric and blood pressure measurements were taken from each participant. Independent sample T-test and Pearson correlation coefficient were used. T2D patients had significantly higher FBG (P= <0.0001), total cholesterol (P= <0.0001), LDL-cholesterol (P= <0.0001), and GGT (P= <0.0001) while, HDL-cholesterol was significantly lower in T2D patients (P= 0.021). In correlation analysis, serum GGT was positively associated with FBG (r= 0.216; P= <0.0001), total cholesterol (r= 0.196; P= 0.0001), triglyceride (r= 0.123; P= 0.038), and LDL-cholesterol (r= 0.209; P= <0.0001). Also, serum ALT was positively associated with FBG (r= 0.145, P= 0.014) and triglyceride (r= 0.172, P= 0.004). We conclude that higher ALT and GGT are used as the predictive biomarkers for NAFLD in T2D patients with hyperlipidemia. Therefore, routine screening of liver enzymes and lipid profile in T2D patients is recommended to detect liver abnormalities and diminish diabetes complications.
Keywords
liver enzymes, dyslipidemia, type 2 diabetes mellitus, Yemeni Patients
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This is a preprint. It has not completed peer review.
Research Article
Lotfi S. Bin Dahman
College of Medicine and Health Sciences, Hadhramout University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1526-4955
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 4
Posted 15 Mar, 2021
No community comments so far
No comments provided
No comments provided
No comments provided
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Declarations:
Declarations
- This study involved human subjects.
- The author confirmed that all appropriate ethical guidelines for the use of human subjects have been followed, any necessary IRB and/or ethics committee review has been obtained, and information about the IRB/ethics committee is included in the manuscript.
- The author has confirmed that all necessary patient/participant consent or assent has been obtained and the appropriate institutional forms have been archived. If the IRB/ethics committee waived the requirement for patient/participant consent or assent, an explanation for the waiver is included in the text.
- This study involved the use of non-human vertebrates.
- The author has confirmed that all appropriate ethical guidelines for the handling and use of animals in research have been followed and details of the oversight board have been included in the text.
- The author has confirmed that a statement listing potential conflicts of interest or lack thereof is included in the text.
The current study was aimed to assess the association between liver enzymes and blood lipid profile in a sample of Yemeni patients with T2D. This is a case-control study comprising 142 T2D patients and 142 healthy control subjects at the Ibn-Sina hospital's outpatient clinics in Mukalla, Yemen. Fasting blood glucose (FBG), total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-cholesterol), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) were determined using Cobas Integra Plus 400 autoanalyzer. Also, anthropometric and blood pressure measurements were taken from each participant. Independent sample T-test and Pearson correlation coefficient were used. T2D patients had significantly higher FBG (P= <0.0001), total cholesterol (P= <0.0001), LDL-cholesterol (P= <0.0001), and GGT (P= <0.0001) while, HDL-cholesterol was significantly lower in T2D patients (P= 0.021). In correlation analysis, serum GGT was positively associated with FBG (r= 0.216; P= <0.0001), total cholesterol (r= 0.196; P= 0.0001), triglyceride (r= 0.123; P= 0.038), and LDL-cholesterol (r= 0.209; P= <0.0001). Also, serum ALT was positively associated with FBG (r= 0.145, P= 0.014) and triglyceride (r= 0.172, P= 0.004). We conclude that higher ALT and GGT are used as the predictive biomarkers for NAFLD in T2D patients with hyperlipidemia. Therefore, routine screening of liver enzymes and lipid profile in T2D patients is recommended to detect liver abnormalities and diminish diabetes complications.
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