Scholars argue that the ‘‘science of science’’ studies have to investigate the critical role of exogenous events in the emergence of new research fields. The goal of this study is to analyze and explain the birth and growth of new research fields driven by exogenous event to science, such as COVID-19 (Coronavirus disease 2019) global pandemic crisis. This study here analyzes how the novel research field of COVID-19 emerges, in a comparative analysis with other scientific fields concerning respiratory illnesses (e.g., Chronic Obstructive Pulmonary Disease, COPD and Lung Cancer), to explain factors determining the unique dynamics of science that is generating scientific breakthroughs in a short period of time. The origin and evolution of the research field of COVID-19 reveal that has an acceleration of scientific production equal to a growth of 1.71% daily in 2020, laying the foundations for science advances and a likely paradigm shift in the treatment of infectious diseases with novel mRNA vaccines. Main results are generalized in properties that clarify the dynamics of science and explain the characteristics that generate the origin and evolution of new research fields driven by unforeseen crises with critical implications for technological and social change directed scientific progress of human societies.