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Research Article
Yeben Qian
Department of General Surgery, First Affiliated Hospital of Anhui Medical University
Corresponding Author
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TMB-related lncrnas and their clinical significance in liver cancer have not been explored.Combining the expression levels of these lncrnas, somatic mutation files and clinical information in patients with liver cancer,we identified 514 lncrnas that are closely related to TMB.Based on these lncrnas, a TMB-derived lncRNA Signature (TMBLncSig) was established. TMBLncSig categorized the patients into high-risk group and low-risk group. There was a significant difference in the prognosis of the patients between the two groups, which was further verified in the independent test set.TMBLncSig is associated with TMB level in liver cancer patients and has the potential to be used as a TMB level measurement tool. In summary this st provide new thought for further study on the role of lncRNA in the difference of TMB level in liver cancer patients.
Keywords
TMB, lncRNA, Hepatic carcinoma
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Yeben Qian
Department of General Surgery, First Affiliated Hospital of Anhui Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 25 Jan, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
TMB-related lncrnas and their clinical significance in liver cancer have not been explored.Combining the expression levels of these lncrnas, somatic mutation files and clinical information in patients with liver cancer,we identified 514 lncrnas that are closely related to TMB.Based on these lncrnas, a TMB-derived lncRNA Signature (TMBLncSig) was established. TMBLncSig categorized the patients into high-risk group and low-risk group. There was a significant difference in the prognosis of the patients between the two groups, which was further verified in the independent test set.TMBLncSig is associated with TMB level in liver cancer patients and has the potential to be used as a TMB level measurement tool. In summary this st provide new thought for further study on the role of lncRNA in the difference of TMB level in liver cancer patients.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
This is a list of supplementary files associated with this preprint. Click to download.
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