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Research article
vegard and eldholm
Folkehelseinstituttet
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6721-3375
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background : The aim of the current study was to improve our understanding of the origins and transmission of Mycobacterium africanum (MAF) in Norway.
Methods : Whole-genome sequences (WGS) were generated for all (n=29) available clinical isolates identified as in Norway in the period 2010 – 2020. Phylogenetic analyses were performed.
Results : The analyses indicated multiple imports of MAF lineage 6 from both East and West African countries, whereas MAF lineage 5 was restricted to patients with West African connections. We also find evidence for transmission of MAF in Norway. Finally, our analyses revealed that a group of isolates from patients originating in South Asia, identified as MAF by means of a commercial line-probe assay, in fact belonged to Mycobacterium orygis.
Conclusions : Most MAF cases in Norway are the result of import, but transmission is occurring in immigrant communities.
Keywords
Mycobacterium africanum, Mycobacterium orygis, transmission, low-incidence country,
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CURRENT STATUS: Under Review
Version 1
Posted 19 Jan, 2021
No community comments so far
Review #2 received
Received 04 Feb, 2021
Editorial decision: Major revision
On 04 Feb, 2021
Review #3 received
Received 03 Feb, 2021
Reviewer #6 agreed
On 18 Jan, 2021
Reviewer #4 agreed
On 17 Jan, 2021
Reviewer #5 agreed
On 17 Jan, 2021
Reviewer #3 agreed
On 17 Jan, 2021
Reviewer #2 agreed
On 16 Jan, 2021
Editor assigned
On 14 Jan, 2021
Reviewers invited
Invitations sent on 14 Jan, 2021
Reviewer #1 agreed
On 14 Jan, 2021
Review #1 received
Received 14 Jan, 2021
Submission checks complete
On 14 Jan, 2021
Editor invited
On 14 Jan, 2021
First submitted
On 10 Jan, 2021
Metrics
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PDF Downloads: ...
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Subject Areas
Infectious Diseases
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at BMC Infectious Diseases. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
vegard and eldholm
Folkehelseinstituttet
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6721-3375
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 19 Jan, 2021
No community comments so far
Review #2 received
Received 04 Feb, 2021
Editorial decision: Major revision
On 04 Feb, 2021
Review #3 received
Received 03 Feb, 2021
Reviewer #6 agreed
On 18 Jan, 2021
Reviewer #4 agreed
On 17 Jan, 2021
Reviewer #5 agreed
On 17 Jan, 2021
Reviewer #3 agreed
On 17 Jan, 2021
Reviewer #2 agreed
On 16 Jan, 2021
Editor assigned
On 14 Jan, 2021
Reviewers invited
Invitations sent on 14 Jan, 2021
Reviewer #1 agreed
On 14 Jan, 2021
Review #1 received
Received 14 Jan, 2021
Submission checks complete
On 14 Jan, 2021
Editor invited
On 14 Jan, 2021
First submitted
On 10 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background : The aim of the current study was to improve our understanding of the origins and transmission of Mycobacterium africanum (MAF) in Norway.
Methods : Whole-genome sequences (WGS) were generated for all (n=29) available clinical isolates identified as in Norway in the period 2010 – 2020. Phylogenetic analyses were performed.
Results : The analyses indicated multiple imports of MAF lineage 6 from both East and West African countries, whereas MAF lineage 5 was restricted to patients with West African connections. We also find evidence for transmission of MAF in Norway. Finally, our analyses revealed that a group of isolates from patients originating in South Asia, identified as MAF by means of a commercial line-probe assay, in fact belonged to Mycobacterium orygis.
Conclusions : Most MAF cases in Norway are the result of import, but transmission is occurring in immigrant communities.
Figure 1
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