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Musa Ceesay
Ministry of Health: Gobierno de Chile Ministerio de Salud
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1004-6139
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: To enhance durable viral suppression and upgrade CD4 cell immune function of HIV-1 proviral DNA positive infants, Gambia government adopted WHO recommended sample collection from infants born to HIV infected mothers before or at 6-8 weeks soon after birth, then ensure 4 weeks’ timeframe from collection dates, through molecular testing, to ART initiation if positive. Despite, studies to determine if these infants sample were collected, tested and initiated on ART within the adopted recommended timeframe, to ensure their achievements of this benefit are lacking.
Aims: We aimed to determine the effect of delayed in diagnosis and ART initiation on CD4 cell and viraemia outcome of HIV-1 proviral DNA positive infants in the Gambia.
Method: 2015-2019 retrospective data collection and analysis of key dates, initial viraemia and CD4 cell outcome, and then prospective cohort study on CD4 cell and viraemia outcome of those followed within at least 6 months and at most 3 years duration on ART adherence. STATA version 13 was used for the data analysis. Delayed in diagnosis and ART initiation was dichotomized using the adopted recommended timeframe, and Pair T-test used to determine the difference between mean initial and mean prospective, CD4 cell and viraemia outcome respectively.
Results: Between 2015-2019, 95 infants were found tested HIV-1 proviral DNA positive among which, 49/95 were found initiated on ART 42 weeks (IQR: 25, 83) median time from their delivery dates. Among these 49, 4 found adhered to the duration in the cohort of those not affect by the delays, difference between their mean initial and prospective CD4 cell outcome was found significantly (P = 0.02) higher than the 11 found adhered to the duration in the cohort of those affected by the delays (P = 0.37).The reverse was found in their viraemia outcome although, not statistically significant for both (P values = O.33 and 0.18 respectively).
Conclusion: The overall 42 weeks median time was found in conflict with the adopted recommended timeframe thus, found affected the CD4 cell and viraemia outcome of positive infants affected by the delays. Henceforth, the urgent attention is required for those affected to improve their prognosis.
Keywords
Early Infant Diagnosis (EID), Human Immunodeficiency Virus (HIV), Antiretroviral Therapy (ART), Delay, The Gambia
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Musa Ceesay
Ministry of Health: Gobierno de Chile Ministerio de Salud
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1004-6139
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 21 Jan, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Virology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: To enhance durable viral suppression and upgrade CD4 cell immune function of HIV-1 proviral DNA positive infants, Gambia government adopted WHO recommended sample collection from infants born to HIV infected mothers before or at 6-8 weeks soon after birth, then ensure 4 weeks’ timeframe from collection dates, through molecular testing, to ART initiation if positive. Despite, studies to determine if these infants sample were collected, tested and initiated on ART within the adopted recommended timeframe, to ensure their achievements of this benefit are lacking.
Aims: We aimed to determine the effect of delayed in diagnosis and ART initiation on CD4 cell and viraemia outcome of HIV-1 proviral DNA positive infants in the Gambia.
Method: 2015-2019 retrospective data collection and analysis of key dates, initial viraemia and CD4 cell outcome, and then prospective cohort study on CD4 cell and viraemia outcome of those followed within at least 6 months and at most 3 years duration on ART adherence. STATA version 13 was used for the data analysis. Delayed in diagnosis and ART initiation was dichotomized using the adopted recommended timeframe, and Pair T-test used to determine the difference between mean initial and mean prospective, CD4 cell and viraemia outcome respectively.
Results: Between 2015-2019, 95 infants were found tested HIV-1 proviral DNA positive among which, 49/95 were found initiated on ART 42 weeks (IQR: 25, 83) median time from their delivery dates. Among these 49, 4 found adhered to the duration in the cohort of those not affect by the delays, difference between their mean initial and prospective CD4 cell outcome was found significantly (P = 0.02) higher than the 11 found adhered to the duration in the cohort of those affected by the delays (P = 0.37).The reverse was found in their viraemia outcome although, not statistically significant for both (P values = O.33 and 0.18 respectively).
Conclusion: The overall 42 weeks median time was found in conflict with the adopted recommended timeframe thus, found affected the CD4 cell and viraemia outcome of positive infants affected by the delays. Henceforth, the urgent attention is required for those affected to improve their prognosis.
This is a list of supplementary files associated with this preprint. Click to download.
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