Allen M, Son L (2020) You Might Be Buying a Hand Sanitizer That Won’t Work for Coronavirus [WWW Document]. ProPublica. URL https://www.propublica.org/ article/coronavirus-hand-sanitizers-cdc-recommended-alcohol.
Agência Nacional de Vigilância Sanitária (ANVISA), 2010 Resolução da DiretoriaColegiada (RDC) No. 42 Dispõesobre a Obrigatoriedade de Disponibilização de Preparação Alcoólica para Fricção Antisséptica das Mãos, pelosServiços de Saúde do País, e DáoutrasProvidências; DiárioOficial da União (DOU), Brasília, de 25/10/2010, p. 27.
Agência Nacional de Vigilância Sanitária (ANVISA) (2012) Brazilian Pharmacopoeia National Form 2nd ed. ANVISA: Brasília.
Andersen KG, Rambaut A, Lipkin WL, Holmes EC, Garry RF (2020) The proximal origin of SARS-CoV-2. Nat Med 26:450–2.
Assefa D, Melaku T (2021) Commercial Hand Sanitizers use amid COVID-19 Pandemic: the Concerns of Antimicrobial Resistance. Infect Drug Resist 14:2183–2185.
Berardi A, Perinelli DR, Merchant HA, Bisharat L, Basheti IA, Bonacucina G, Cespi M, Palmier GF (2020b) Hand sanitisers amid CoViD-19: A critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand. Int J Pharm 584:119431.
Bråred CJ, Hagvall L, Karlberg A-T (2016) Fragrance Allergens, Overview with a Focus on Recent Developments and Understanding of Abiotic and Biotic Activation. Cosmetics 3(2):19.
Bomgardner MM, Mullin R, Scott A (2020) Stepping up to the hand sanitizer shortage. Chem Eng NEWS 98(11).
CDC (2019a) Show Me the Science – When & How to Use Hand Sanitizer in Community Settings [WWW Document]. URL https://www.cdc.gov/handwashing/show-me-thescience-hand-sanitizer.html (accessed 4.15.20)
CDC (2022) What You Need to Know About Variants, Updated Feb. 25, 2022. https://www.cdc.gov/coronavirus/2019-ncov/variants/about-variants.html
Chu DK, Akl EA, Duda S, Solo K, Yaacoub S, Schünemann HJ (2020) Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet 395:1973–1987.
Correia RM, Domingos E, Cáo VM, Araujo BRF, Sena S, Pinheiro LU, Fonte AM, Aquino LFM, Ferreira EC, Filgueiras PR, Romão W (2018) Portable near infrared spectroscopy applied to fuel quality control. Talanta 176:26–33.
CSSE JHU (2020) Coronavirus COVID-19 Global Cases by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU).
Daniel W et al. (2020) Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 367:1260–63.
Delirrad M, Mohammadi AB (2020) New methanol poisoning outbreaks in Iran following covid-19 pandemic. Alcohol Alcohol 55(4):347–348.
Dear K, Grayson L, Nixon R (2020) Potential methanol toxicity and the importance of using a standardised alcohol-based hand rub formulation in the era of COVID-19. Antimicrob Resist Infect Control 9(1):129.
Dhama K, Patel SK, Kumar R, Masand R, Rana J, Yatoo, Mohd I, Tiwari R, Sharun K, Mohapatra RK, Natesan S, Dhawan M, Ahmad T, Emran TB, Malik YS, Harapan H (2021) The role of disinfectants and sanitizers during COVID-19 pandemic: advantages and deleterious effects on humans and the environment. Environ Sci Pollut Res 28:34211–34228. https://doi. org/10. 1007/ s11356- 021- 14429-w
European Centre for Disease Prevention and Control. Threat assessment brief: emergence of SARS-CoV-2 B.1.617 variants in India and situation in the EU/EEA. May 11, 2021 (https://www.ecdc.europa.eu/ en/publications-data/threat-assessment -emergence-sars-cov-2-b1617-variants).
Elbe S, Buckland-Merrett G (2017) Data, disease and diplomacy: GISAID’s innovative contribution to global health. Glob Chall 1:33–46.
Edmonds SL, Macinga DR, Mays-Suko P, Duley C, Rutter J, Jarvis WR, Arbogast JW (2012) Comparative efficacy of commercially available alcohol-based hand rubs and World Health Organization-recommended hand rubs: Formulation matters. Am J Infect Control 40:521–525.
Fonseca Jr. FS, Brito LRe, Pimentel MF, Leal LB (2020) Determination of Ethanol in Gel Hand Sanitizers Using Mid and Near Infrared Spectroscopy. J Braz Chem Soc 31(9): 1759-1763.
Fehr AR et al. (2015) Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol 1282:1–23.
Gharpure R, Hunter CM, Schnall AH et al. (2020) Knowledge and practices regarding safe household cleaning and disinfection for COVID-19 prevention – United States, May 2020. MMWR Morb Mortal Wkly Rep 69(23):705–709.
Gormley NJ, Bronstein AC, Rasimas JJ et al. (2012) The rising incidence of intentional ingestion of ethanol-containing hand sanitizers. Crit Care Med 40(1):290–294.
Golin AP, Choi D, Ghahary A (2020) Hand sanitizers: a review of ingredients, mechanisms of action, modes of delivery, and efficacy against coronaviruses. Am J Infect Control 48:1062–7.
Gold NA, Avva U (2020) Alcohol Sanitizer, in: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing.
Hand hygiene recommendations (2020). Available from: https://www. cdc.gov/coronavirus/2019-ncov/hcp/hand-hygiene.html. Accessed February 24, 2021.
Hart WS, Miller E, Andrews NJ, Waight P, Maini PK, Funk S, Thompson RN. Generation time of the alpha and delta SARS-CoV-2 variants: an epidemiological analysis. The Lancet Infectious Diseases. 2022 Feb 14.
Hertzog JH, Radwick A (2015) Acute Alcohol Intoxication in a Child Following Ingestion of an Ethyl-Alcohol-Based Hand Sanitizer. Int J Clin Pharmacol Ther 53:557–560.
Hadaway A (2020) Handwashing: Clean Hands Save Lives. J Consum Health Internet 24:43–49.
Howes L (2020) What is hand sanitizer, and does it keep your hands germ-free? Chem Eng NEWS Volume: 98.
Huddleston JT (2020) The history of hand sanitizer—how the coronavirus staple went from mechanic shops to consumer shelves [WWW Document]. URL https://www.cnbc.com/2020/03/27/coronavirus-the-history-of-hand-sanitizer-and-why-its-important.html
Holzmana SD, Larsena J, Kaura R, Smelskia G, Dudleya S, Shirazia FM (2021) Death by hand sanitizer: syndemic methanol poisoning in the age of COVID-19, Clin Toxicol 59(11):1009-1014.
Hulshof PB, Veenstra J, van Zwieten R (2019) Severe hemolytic anemia due to transient acquired G6PD deficiency after ingestion of sodium chlorite. Clin Toxicol 57(1):65–66.
Inder D, Kumar P (2020) Isopropyl alcohol (70%)-based hand sanitizer-induced contact dermatitis: A case report amid Covid-19. Indian J Case Rep 6(6):403–405.
Ingram LO (1976) Adaptation of membrane lipids to alcohols. J Bacteriol 125:670–8.
Jairoun AA, Al-Hemyari SS, Shahwan M (2021) The pandemic of COVID-19 and its implications for the purity and authenticity of alcohol-based hand sanitizers: the health risks associated with falsified sanitizers and recommendations for regulatory and public health bodies. Res Social Adm Pharm 17(1):2050–2051.
Jakasa I, Thyssen JP, Kezic S (2018) The role of skin barrier in occupational contact dermatitis. Exp Dermatol 27(8):909–914.
Joseph MM, Zeretzke C, Reader S, Sollee DR (2011) Acute Ethanol Poisoning in a 6-Year-Old Girl Following Ingestion of Alcohol-Based Hand Sanitizer at School. World J Emerg Med 2:232–233.
Johansen JD (2003) Fragrance contact allergy: a clinical review. Am J Clin Dermatol 4(11):789–798.
Kampf G, Kramer A, Suchomel M (2017) Lack of sustained efficacy for alcohol-based surgical hand rubs containing ‘residual active ingredients’ according to EN 12791. J Hosp Infect 95:163–168.
Kampf G, Kramer A (2004) Epidemiologic background of hand hygiene and evaluation of the most important agents for scrubs and rubs. Clin Microbiol Rev 17:863–893.
Kampf G (2004) The six golden rules to improve compliance in hand hygiene. J Hosp Infect, 56 Suppl 2:S3– 5.
Kramer A, Rudolph P, Kampf G, Pittet D (2002) Limited efficacy of alcohol-based hand gels. Lancet 359:1489–1490.
Kraut JA, Mullins ME (2018) Toxic alcohols. N Engl J Med 378(3):270–280.
Lai -C-C, Shih T-P, Ko W-C, Tang H-J., Hsueh P-R (2020) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges. Int J Antimicrob Agents 55(3):105924.
Larson E, Girard R, Pessoa-Silva CL, Boyce J, Donaldson L, Pittet, D (2006) Skin reactions related to hand hygiene and selection of hand hygiene products. Am J Infect Control, 34(10):627–635.
Lebin JA, Ma A, Mudan A, Smollin CG (2021). Fatal ingestion of sodium chlorite used as hand sanitizer during the COVID-19 pandemic. Clin Toxicol 59(3):265-266.
Li Q, Guan X, Wu P et al. (2020) Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 382:1199–1207.
Lu R et al. (2020) Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet (London, England) 395:565–74.
Master Brewers Association of the Americas (MBAA) (2020) Manufacturing Hand Sanitizer in the Brewery #167. Master Brewers Podcast.
Mahmood A, Eqan M, Pervez S, Alghamdi HA, Tabinda AB, Yasar A, Brindhadevi K, Pugazhendhi A (2020) COVID-19 and frequent use of hand sanitizers; human health and environmental hazards by exposure pathways. Sci Total Environ 742:140561.
Naissan O, Wesley TL (2020) Hand washing and hand sanitizer on the skin and COVID-19 infection risk. Available from: https:// www.the-hospitalist.org/hospitalist/article/219484/aestheticdermatology/hand-washing-and-hand-sanitizer-skin-and-covid-19/ page/0/2. Accessed June 18, 2020.
Nascimento RJA, Macedo GR, Santos ES, Oliveira JA (2017) Real Time and in Situ Near-infrared Spectroscopy (nirs) for Quantitative Monitoring of Biomass, Glucose, Ethanol and Glycerine Concentrations in an Alcoholic Fermentation. Braz J Chem Eng 34:459.
Nhung DTT, Freydiere A-M, Constant H, Falson F, Pirot F (2007) Sustained antibacterial effect of a hand rub gel incorporating chlorhexdine-loaded nanocapsules (Nanochlorex®). Int J Pharm 334:166–172.
Ophaswongse S, Maibach HI (1994) Alcohol dermatitis: allergic contact dermatitis and contact urticaria syndrome: A review. Contact Derm 30(1):1–6.
O’Leary FM, Price GJ (2011) Alcohol hand gel–a potential fire hazard. J Plast Reconstr Aesthet Surg 64(1):131–132.
Parveen, N, Chowdhury, S, Goel, S (2022). Environmental impacts of the widespread use of chlorine-based disinfectants during the COVID-19 pandemic. Environ Sci Pollut Res, 1-19. https://doi.org/10.1007/s11356-021-18316-2
Paulson DS, Fendler EJ, Dolan MJ, Williams RA (1999). A close look at alcohol gel as an antimicrobial sanitizing agent. Am J Infec Control 27:332–338.
Perinelli DR, Berardi A, Bisharat L, Cambriani A, Ganzetti R, Bonacucina G, Cespi M, Palmieri GF (2021) Rheological properties of cellulosic thickeners in hydro-alcoholic media: The science behind the formulation of hand sanitizer gels. Int J Pharm 604: 120769.
Phillips T, Schulte JM, Smith EA, Roth B, Kleinschmidt KC (2021) COVID-19 and contamination: impact on exposures to alcohol-based hand sanitizers reported to Texas Poison Control Centers. Clin Toxicol 59(10):926-931.
Rotter M (1999) Hand washing and disinfection. In: Mayhall CG, editor. Hospital Epidemiology and Infection Control. 2nd ed. Baltimore: Williams and Wilkins, 1339–1355.
Singh D et al. (2020) Alcohol-based hand sanitizers as first line of defence against SARS-CoV-2: a review of biology, chemistry and formulations. Epidemiol Infect., 148, e229, 1–9.
SIFAP (2020) Newsletter 26 Febbraio 20020 [WWW Document]. URL https://www.sifap. org/newsletter/emergenza-sanitaria-coronavirus,-chiarimenti-per-il-farmacista-pr eparatore (accessed 4.16.20).
Todd ECD, Michaels BS, Holah J, Smith D, Greig J.D., Bartleson CA (2010) Outbreaks Where Food Workers Have Been Implicated in the Spread of Foodborne Disease. Part 10. Alcohol-Based Antiseptics for Hand Disinfection and a Comparison of Their Effectiveness with Soaps. J Food Prot 73:2128–2140.
Thomson EL, Bullied AR (2020) Corrosion Resistance of Aluminum Beer Cans Containing Hand Sanitizer. J Am Soc Brew Chem 78(4):279–283.
UfficioStudi Coop (2020) Fornai, pasticceri e pizzaioli. Gliitalianiai tempi del Covid19 [WWW Document].
U.S. Department of Health and Human Services, Food and Drug Administration (FDA), Center for Drug Evaluation and Research (CDER); Temporary Policy for Manufacture of Alcohol for Incorporation into Alcohol-Based Hand Sanitizer Products During the Public Health Emergency (COVID-19); CDER: Rockville, USA (2020).
van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, Tamin A, Harcourt JL, Thornburg NJ, Gerber SI, Lloyd-Smith JO, de Wit E, Munster VJ (2020) Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med 382(16):1564–1567. https://doi.org/10.1056/NEJMc2004973
Voller LM, Schlarbaum JP, Hylwa SA (2021) Allergenic Ingredients in Health Care Hand Sanitizers in the United States. Dermatitis 32(3):151-159.
Vujasinović M, Kočar M, Kramer K et al. (2007) Poisoning with 1-propanol and 2-propanol. Hum Exp Toxicol 26(12):975–978.
Wanderlingh U, D'Angelo G, Nibali VC, Crupi C, Rifici S, Corsaro C, Sabatino G (2010) Interaction of alcohol with phospholipid membrane: NMR and XRD investigations on DPPC–hexanol system. Spectroscopy 24:375–80.
WHO. Novel Coronavirus–China (2020) Available from: https:// www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/. Accessed June 10, 2020.
WHO Coronavirus disease (COVID-19) advice for the public. Published 2020. Accessed September 12, 2020. https://www.who.int/emergencies/diseases/novel-coronavirus2019/advice-for-public.
WHO (2021) Update on Omicron, WHO News.
WHO (2021) Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern, WHO News.
WHO (2019) Coronavirus disease (COVID-19) advice for the public; 2021. Available from: https://www.who.int/emergencies/diseases/ novel-coronavirus-2019/advice-for-public. Accessed June 18, 2020.
WHO Guide to local production: WHO-recommended handrub formulations. Published online 2010. Accessed September 12, 2020. https://www.who.int/gpsc/5may/Guide_to_Local_Production.pdf?ua=1.
Wolfe MK, Gallandat K, Daniels K, Desmarais AM, Scheinman P, Lantagne, D (2017) Handwashing and Ebola virus disease outbreaks: a randomized comparison of soap, hand sanitizer, and 0.05% chlorine solutions on the inactivation and removal of model organisms Phi6 and E. coli from hands and persistence in rinse water. PLoS One12(2):e0172734.
Yip L, Bixler D, Brooks DE et al. (2020) Serious Adverse Health Events, Including Death, Associated with Ingesting Alcohol-Based Hand Sanitizers Containing Methanol - Arizona and New Mexico, May-June 2020. Morb Mortal Wkly Rep 69(32):1070–1073. https://www.cdc.gov/mmwr/volumes/69/wr/mm6932e1.htm#contribAff