Painful subacute thyroiditis (PF-SAT) after viral vaccinations is a rare but often go unnoticed. A viral infection and some viral vaccinations may cause PF-SAT as an undesired consequence. Presenting symptoms are sore throat, weight loss, sleep disturbances and palpitation which all are quite similar to those seen in thyrotoxicosis. In the early phase of the illness, hyper thyroid function is a rule, followed by euthyroid and rarely hypo-thyroid phases. Treatment for SAT is usually successful with a very rare recurrence. Here, we report a case of PF-SAT, after immunization with whole virion inactivated Covid-19 vaccine, in a health care worker.