After the strict screening, 24 patients were eligible for orthotopic ileal neobladder. They were randomized into group A (iodophor group), group B (anhydrous Ethanol), and group C (chlorhexidine acetate group) and treated with mucosa treatment agents 8 in each group.
In group A, 6 males and 2 females, were aged (62.0 ± 11.3) years, BMI (25.2 ± 4.1) kg / m2, and preoperative tumor size (4.76 ± 3.06) cm. Among them, 3 patients had hypertension, 2 patients had diabetes mellitus, 4 patients had no smoking history, 2 patients had undergone TURBT and relapsed again. In group A, preoperative hemoglobin was (128.5 ± 18.3) g / L, and preoperative albumin was (37.6 ± 3.3) g / L.In group B, 7 males and 1 female, age of (58.8 ± 10.6) years, a BMI of (24.8 ± 4.7) kg / m2, and preoperative tumor size of (4.34 ± 3.20) cm. Among them, 2 patients had hypertension, 1 patient had diabetes mellitus, 3 patients had no smoking history, 1 patient had undergone TURBT and recurred after the operation. In group B, preoperative hemoglobin was (132.3 ± 15.8) g / L, and preoperative albumin was (38.4 ± 343) g / L.
In group C, 7 males and 1 female, age of (61.3 ± 12.7) years, a BMI of (25.4 ± 4.3) kg / m2, and preoperative tumor size of (4.87 ± 3.46) cm. Among them, 4 patients had hypertension, 2 patients had diabetes mellitus, 2 patients had no smoking history, 3 patients had undergone TURBT and relapsed again. In group C, preoperative hemoglobin was (130.5 ± 17.5) g / L, and preoperative albumin were (39.6 ± 2.3) g / L.
All 24 cases were operation completed successfully. The operation time of groups A, B, and C were (275 ± 20.62) min, (280.1 ± 19.76) min, and (290 ± 21.27) min, respectively (P = 0.3498), no statistical difference. There is no significant difference among the three groups: intraoperative blood loss, postoperative NPO, drainage time, neobladder surface area, postoperative TNM stage, postoperative lymph node status, and pathological grading, no significant difference among the three groups (P > 0.05).
Statistics of postoperative complications
Three patients in group A had catheter blockage on follow-up for a year, but not in group B and C, P = 0.048 < 0.05, with a statistical difference. There was no significant difference in other related complications (P > 0.05), indicating that catheter blockage incidence in patients treated with Iodophor was significantly higher than in the other two groups, with statistical significance [Table 1].
Mucus secretion of neobladder after different treatments
Most patients did not eat on POD 1st and 2nd, and no new mucus secretion. Neobladder mucus mainly came from epithelial tissue shedding and a new bladder's blood clot. These data errors were too large, so we removed mucus volume data of POD 1st and 2nd. Hence, we decided to analyze data from 3-14 days [Table 1]. The graph shows the secretion of intestinal mucus has a certain regularity, which gradually begins to secrete on the POD 3RD, reaches the peak on the 7th, and then gradually decreases but does not disappear. The mucus secretion in the iodophor group was significantly higher than that in the chlorhexidine acetate and absolute ethanol groups. The mucus secretion in the chlorhexidine acetate and absolute ethanol groups was similar, with no significant difference.The weight of mucus secretion per unit area of the neobladder was calculated according to the mucus weight of three groups of neobladder after irrigation.
Analysis of variance among groups A, B, and C
The mucus secretion of the Iodophor, anhydrous Ethanol, and chlorhexidine acetate groups are different within 3-14 days. We Compared the mucus secretion of the neobladder in the anhydrous ethanol group and chlorhexidine acetate group within 3-14 days. We found no statistical difference in the anhydrous Ethanol and chlorhexidine acetate groups. The mucus secretion was more after the operation (P < 0.01) [Figure 1].