Abstract
Dietary habits and exercise play important roles in wellbeing of human health. Currently, how long of drinking tea with exercise could be efficiently ameliorating hepatic steatosis and obesity complication still need to be investigated. Here, we comparatively explored short and long term green tea consumption plus exercise improve hepatic steatosis and obesity complication in high fat diet (HFD) mice. Our results showed that Yunkang 10 green tea (YKGT) plus exercise exhibited synergistic prevention effects on ameliorating hepatic steatosis and obesity complication at the 8-week intervention. Moreover, 22-week intervention with YKGT or exercise improved all symptoms of obesity complication, which indicated that long term intervention exhibited profound preventive effects than short term. All treatments inhibited NF-κB activation and pro-inflammatory cytokine expression at both 8- and 22-week intervention, indicated that inflammation may be a cause event for developing hepatic steatosis. The key molecules for regulating lipid and glucose metabolism SCD1 were obviously down-regulated, and GLU2 and PPARγ were significantly up-regulated by YKGT and exercise in the liver of HFD mice. This study demonstrated that long term intervention with YKGT and exercise effectively relieved hepatic steatosis and obesity complication by ameliorating hepatic inflammation, reducing lipid synthesis and accelerating glucose transport.