Platelet-Rich Plasma becomes more and more popular treatment alternative or additional method in androgen alopecia (AGA). AGA is a multifactorial disease, in which testosterone plays a significant role in influencing hair growth. The aim was to evaluate the effectiveness of PRP treatment in androgenetic alopecia affecting men. The research was performed using the following databases: PubMed, Embase, and Cochrane Library. The effects were measured with a Tricho-Scan and the measure of the effect was the difference between the initial and final hair density. A significant difference was observed between the areas of the scalp where PRP injections were made and those where saline was administered. Compared to conventional minoxidil 5% topical platelet-rich plasma therapy PRP is more effective in male-pattern baldness treatment. A beneficial effect of combining PRP Therapy with minoxidil 5% was observed, therefore PRP is not only an excellent alternative for patients in whom the minoxidil 5% topical monotherapy did not bring the expected effect or experienced unacceptable side effects, but also can be used as a complementary therapy.