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Research article
Zhiming Lin
Third Affiliated Hospital of Sun Yat-Sen University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9341-4303
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objectives: This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients.
Method: A cross-sectional study recruits 1,398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Risk factors for bone loss in rheumatic patients are analyzed by logistic regression.
Results: (1) Rheumatic patients are consisted of 40.0% rheumatoid arthritis (RA), 14.7% systemic lupus erythematosus (SLE), 14.2% osteoarthritis (OA), 9.2% ankylosing spondylosis (AS), 7.9% gout, 7.0% primary Sjogren syndrome (pSS), 3.8% systemic sclerosis (SSc), and 3.2% mixed connective tissue disease (MCTD). (2) In male patients aged under 50 and premenopausal female patients, the bone mineral density score of AS (53.9%, P<0.001) and SLE (39.6%, P=0.034) patients is lower than the healthy controls (18.2%). (3) Osteopenia and osteoporosis are more prevailing in male patients aged or older than 50 and postmenopausal female patients with RA (P<0.001), OA (P=0.02) and SLE (P =0.011) than healthy counterparts. (4) Those with SLE, RA and AS gain the highest odd ratio of ‘score below the expected range for age’, osteopenia and osteoporosis, respectively. (5) Age, female, low BMI and hypovitaminosis D are found negatively associated with bone loss. Dyslipidemia and hyperuricemia could be protective factors.
Conclusion: Young patients with AS and SLE have a significant higher occurrence of bone loss, and older patients with RA, OA and SLE had higher prevalence than healthy counterparts. SLE, RA, SSc and AS were founded significant higher risks to develop into bone loss after adjustment. Age, BMI and gender were commonly-associated with bone loss in all age-stratified rheumatic patients. These findings were not markedly different from those of previous studies.
Keywords
rheumatic patients, bone mineral density, osteopenia, osteoporosis
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CURRENT STATUS: Published
View the published article at BMC Musculoskeletal Disorders.
Version 2
Posted 28 May, 2020
No community comments so far
Review #1 received
Received 26 May, 2020
Reviewer #2 agreed
On 22 May, 2020
Review #2 received
Received 22 May, 2020
Reviewers invited
Invitations sent on 20 May, 2020
Reviewer #1 agreed
On 20 May, 2020
Editor assigned
On 19 May, 2020
Submission checks complete
On 19 May, 2020
Editor invited
On 18 May, 2020
No comments provided
Editorial decision: Minor revision
On 06 May, 2020
Review #2 received
Received 05 May, 2020
Reviewer #3 agreed
On 28 Apr, 2020
Review #1 received
Received 07 Apr, 2020
Reviewer #2 agreed
On 30 Mar, 2020
Reviewer #1 agreed
On 10 Mar, 2020
Reviewers invited
Invitations sent on 04 Mar, 2020
Editor assigned
On 02 Mar, 2020
Submission checks complete
On 26 Feb, 2020
Editor invited
On 25 Feb, 2020
First submitted
On 14 Feb, 2020
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PDF Downloads: ...
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Subject Areas
Orthopedics
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See the published version of this preprint at BMC Musculoskeletal Disorders.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Zhiming Lin
Third Affiliated Hospital of Sun Yat-Sen University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9341-4303
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Musculoskeletal Disorders.
Version 2
Posted 28 May, 2020
No community comments so far
Review #1 received
Received 26 May, 2020
Reviewer #2 agreed
On 22 May, 2020
Review #2 received
Received 22 May, 2020
Reviewers invited
Invitations sent on 20 May, 2020
Reviewer #1 agreed
On 20 May, 2020
Editor assigned
On 19 May, 2020
Submission checks complete
On 19 May, 2020
Editor invited
On 18 May, 2020
No comments provided
Editorial decision: Minor revision
On 06 May, 2020
Review #2 received
Received 05 May, 2020
Reviewer #3 agreed
On 28 Apr, 2020
Review #1 received
Received 07 Apr, 2020
Reviewer #2 agreed
On 30 Mar, 2020
Reviewer #1 agreed
On 10 Mar, 2020
Reviewers invited
Invitations sent on 04 Mar, 2020
Editor assigned
On 02 Mar, 2020
Submission checks complete
On 26 Feb, 2020
Editor invited
On 25 Feb, 2020
First submitted
On 14 Feb, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Orthopedics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Musculoskeletal Disorders.
Objectives: This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients.
Method: A cross-sectional study recruits 1,398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Risk factors for bone loss in rheumatic patients are analyzed by logistic regression.
Results: (1) Rheumatic patients are consisted of 40.0% rheumatoid arthritis (RA), 14.7% systemic lupus erythematosus (SLE), 14.2% osteoarthritis (OA), 9.2% ankylosing spondylosis (AS), 7.9% gout, 7.0% primary Sjogren syndrome (pSS), 3.8% systemic sclerosis (SSc), and 3.2% mixed connective tissue disease (MCTD). (2) In male patients aged under 50 and premenopausal female patients, the bone mineral density score of AS (53.9%, P<0.001) and SLE (39.6%, P=0.034) patients is lower than the healthy controls (18.2%). (3) Osteopenia and osteoporosis are more prevailing in male patients aged or older than 50 and postmenopausal female patients with RA (P<0.001), OA (P=0.02) and SLE (P =0.011) than healthy counterparts. (4) Those with SLE, RA and AS gain the highest odd ratio of ‘score below the expected range for age’, osteopenia and osteoporosis, respectively. (5) Age, female, low BMI and hypovitaminosis D are found negatively associated with bone loss. Dyslipidemia and hyperuricemia could be protective factors.
Conclusion: Young patients with AS and SLE have a significant higher occurrence of bone loss, and older patients with RA, OA and SLE had higher prevalence than healthy counterparts. SLE, RA, SSc and AS were founded significant higher risks to develop into bone loss after adjustment. Age, BMI and gender were commonly-associated with bone loss in all age-stratified rheumatic patients. These findings were not markedly different from those of previous studies.
Figure 1
Figure 2
Figure 3
Figure 4
This is a list of supplementary files associated with this preprint. Click to download.
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