Background Preoperative platelet distribution width-to-platelet count ratio (PDW/PLT) has been discussed about its prognostic value in several malignancies, whereas its role in bladder cancer remains unclear. In this study, we attempt to investigate the relationship between the PDW/PLT and the prognosis of patients with bladder cancer.
Patients and Methods The clinical data of 115 cases of bladder cancer treated in urology department of Nantong tumor hospital from January 2009 to August 2014 were analyzed retrospectively. The best critical value of PDW/PLT was 0.09965 determined by ROC curve. The patients were divided into low PDW/PLT group and high PDW/PLT group. After 5 years of follow-up, survival was observed, and the clinicopathological data of patients were statistically analyzed. Kaplan Meier method and log rank test were used for single factor survival analysis, and Cox regression analysis was used for multiple factors survival analysis.
Results The age of patients in low PDW/PLT group was significantly lower than that in high PDW/PLT group (P=0.008). There was no significant difference between the two groups in gender, TNM stage, grade, lymph node metastasis, distant metastasis, operation method, history of hypertension, history of diabetes, and other operation history (P>0.05). All patients were followed up for 5 years. 89 patients survived, the survival rate was 77.4%, 26 patients died, the mortality rate was 22.6%. There were 94 cases (81.7%) in low PDW/PLT group and 21 cases (18.3%) in high PDW/PLT group. The tumor progression rates of low PDW/PLT group and high PDW/PLT group were 57.4% (54/94) and 71.4% (15/21) respectively. The median PFS was 85 months and 71 months respectively. There was no significant difference between the two groups (P>0.05). Single factor analysis showed that TNM stage, grade, lymph node metastasis, PDW/PLT were the factors affecting OS (P<0.05). The results of Cox multivariate analysis showed that PDW/PLT was an independent risk factor for tumor progression (P＜0.05). The increase of PDW/PLT can significantly reduce OS and PFS in patients with bladder cancer.
Conclusions PDW/PLT is an independent prognostic factor in patients with bladder cancer, and it is related to the clinicopathological characteristics. It has a certain value in evaluating the prognosis of patients with bladder cancer.