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Research Article
Yingmei Feng
Capital Medical University
Corresponding Author
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Whereas the adverse impact of fine particulate matter on coronary heart disease and respiratory disorders has been clarified, its influence on glomerular function is not well defined in population studies. Serum creatinine levels were quantified in 820 randomly recruited people (50.7% women; mean age 51.1 years). Among them, 653 participants were followed up for a median of 4.8 years. Using multivariable-adjusted mixed model, eGFR (or serum creatinine) both at baseline and follow-up were regressed against long term residential black carbon (BC) or PM2.5 (particles with an aerodynamic diameter ≤2.5 µm). In longitudinal analysis, the percent change in eGFR was regressed against long term residential exposure to BC or PM2.5. eGFR averaged 80.9 (SD 16.4) mL/min/1.73m2 and median long term PM2.5 and black carbon amounted 13.1 (SD 0.92) and 1.10 (SD 0.19) µg/m³, respectively. In multivariable-adjusted cross-sectional analyses, eGFR was unrelated to BC and PM2.5 (P ≥ 0.59). During follow-up, eGFR decreased on average by 1.9 mL/min/1.73m2 (95% confidence interval: 1.0-2.8). The percentage decline in eGFR was not significantly associated with either BC or PM2.5 (P ≥ 0.75). In conclusion, long-term residential exposure to PM2.5 and black carbon is not associated with eGFR decline in predominantly healthy people drawn from a general semirural population.
Keywords
black carbon, chronic kidney disease, eGFR, PM2.5, population science, renal function
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See the published version of this preprint at Scientific Reports.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Yingmei Feng
Capital Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Scientific Reports.
Version 1
Posted 02 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 07 Apr, 2021
Reviews received
Received 23 Mar, 2021
Reviewers agreed
On 22 Mar, 2021
Reviewers agreed
On 12 Mar, 2021
Reviewers invited
Invitations sent on 12 Mar, 2021
Editor assigned
On 12 Mar, 2021
Editor invited
On 02 Feb, 2021
Submission checks complete
On 01 Feb, 2021
First submitted
On 23 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Scientific Reports.
Whereas the adverse impact of fine particulate matter on coronary heart disease and respiratory disorders has been clarified, its influence on glomerular function is not well defined in population studies. Serum creatinine levels were quantified in 820 randomly recruited people (50.7% women; mean age 51.1 years). Among them, 653 participants were followed up for a median of 4.8 years. Using multivariable-adjusted mixed model, eGFR (or serum creatinine) both at baseline and follow-up were regressed against long term residential black carbon (BC) or PM2.5 (particles with an aerodynamic diameter ≤2.5 µm). In longitudinal analysis, the percent change in eGFR was regressed against long term residential exposure to BC or PM2.5. eGFR averaged 80.9 (SD 16.4) mL/min/1.73m2 and median long term PM2.5 and black carbon amounted 13.1 (SD 0.92) and 1.10 (SD 0.19) µg/m³, respectively. In multivariable-adjusted cross-sectional analyses, eGFR was unrelated to BC and PM2.5 (P ≥ 0.59). During follow-up, eGFR decreased on average by 1.9 mL/min/1.73m2 (95% confidence interval: 1.0-2.8). The percentage decline in eGFR was not significantly associated with either BC or PM2.5 (P ≥ 0.75). In conclusion, long-term residential exposure to PM2.5 and black carbon is not associated with eGFR decline in predominantly healthy people drawn from a general semirural population.
Figure 1
Figure 2
No competing interests reported.
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