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Research Article
Olli Paul Einari Rajasilta
University of Turku
Corresponding Author
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Introduction: Maternal obesity/overweight during pregnancy has reached epidemic proportions and has been linked with adverse outcomes for the offspring, including cognitive impairment and increased risk for neuropsychiatric disorders. Prior neuroimaging investigations have reported widespread aberrant functional connectivity and white matter tract abnormalities in neonates born to obese mothers. Here we explored whether maternal pre-pregnancy adiposity is associated with alterations in local neuronal synchrony in the neonate brain.
Methods: 21 healthy mother-neonate dyads from uncomplicated pregnancies were included in this study (age at scanning 26.14 ± 6.28 days, 12 male). The neonates were scanned with a 6-minute resting-state functional magnetic resonance imaging (rs-fMRI) during natural sleep. Regional homogeneity (ReHo) maps were computed from obtained rs-fMRI data. Multiple regression analysis was performed to assess the association of pre-pregnancy maternal body-mass-index (BMI) and ReHo.
Results: Maternal adiposity measured by pre-pregnancy BMI was positively associated with neonate ReHo values within the left superior frontal gyrus (FDR/FWE –corrected p < 0.005).
Conclusions: Our results imply that maternal pre-pregnancy BMI associates with local functional synchrony within the neonate left superior frontal gyrus. In line with previous studies, our findings indicate that maternal pre-pregnancy BMI has a programming influence on the developing neonate brain functional networks.
Keywords
Neonatal, Resting-state functional magnetic resonance imaging, Regional homogeneity, Maternal pre-pregnancy BMI, Development
Figure 1
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
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CURRENT STATUS: Under Review
Version 1
Posted 29 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 15 Feb, 2021
Reviews received
Received 12 Feb, 2021
Reviews received
Received 09 Feb, 2021
Reviewers agreed
On 03 Feb, 2021
Reviewers agreed
On 02 Feb, 2021
Reviewers invited
Invitations sent on 02 Feb, 2021
Editor assigned
On 02 Feb, 2021
Editor invited
On 27 Jan, 2021
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On 27 Jan, 2021
First submitted
On 23 Jan, 2021
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A new preprint design is coming!
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Olli Paul Einari Rajasilta
University of Turku
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 29 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 15 Feb, 2021
Reviews received
Received 12 Feb, 2021
Reviews received
Received 09 Feb, 2021
Reviewers agreed
On 03 Feb, 2021
Reviewers agreed
On 02 Feb, 2021
Reviewers invited
Invitations sent on 02 Feb, 2021
Editor assigned
On 02 Feb, 2021
Editor invited
On 27 Jan, 2021
Submission checks complete
On 27 Jan, 2021
First submitted
On 23 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Introduction: Maternal obesity/overweight during pregnancy has reached epidemic proportions and has been linked with adverse outcomes for the offspring, including cognitive impairment and increased risk for neuropsychiatric disorders. Prior neuroimaging investigations have reported widespread aberrant functional connectivity and white matter tract abnormalities in neonates born to obese mothers. Here we explored whether maternal pre-pregnancy adiposity is associated with alterations in local neuronal synchrony in the neonate brain.
Methods: 21 healthy mother-neonate dyads from uncomplicated pregnancies were included in this study (age at scanning 26.14 ± 6.28 days, 12 male). The neonates were scanned with a 6-minute resting-state functional magnetic resonance imaging (rs-fMRI) during natural sleep. Regional homogeneity (ReHo) maps were computed from obtained rs-fMRI data. Multiple regression analysis was performed to assess the association of pre-pregnancy maternal body-mass-index (BMI) and ReHo.
Results: Maternal adiposity measured by pre-pregnancy BMI was positively associated with neonate ReHo values within the left superior frontal gyrus (FDR/FWE –corrected p < 0.005).
Conclusions: Our results imply that maternal pre-pregnancy BMI associates with local functional synchrony within the neonate left superior frontal gyrus. In line with previous studies, our findings indicate that maternal pre-pregnancy BMI has a programming influence on the developing neonate brain functional networks.
Figure 1
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
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