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Research article
Sachiyuki Tsukada
Hokusuikai Kinen Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1186-5232
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Beta-lactam antibiotics are frequently selected as initial intravenous empirical therapy in acute periprosthetic joint infection (PJI), but show poor drug migration to the knee joint.
Methods: We retrospectively assessed 23 patients undergoing irrigation and debridement surgery for acute PJI after primary TKA. First, we compared the success rate of implant retention between patients receiving beta-lactam antibiotics as initial intravenous empirical therapy and those receiving antibiotics other than beta-lactams. Second, multivariate logistic regression analysis was used to control for confounding factors and to distinguish independent risk factors for the failure of implant retention.
Results: Twelve patients received beta-lactam antibiotics as initial intravenous therapy (67% received cefazolin) and 11 patients received antibiotics other than beta-lactams (82% received linezolid). Patients receiving beta-lactam antibiotics had significantly lower implant retention rate than those receiving other antibiotics (5 of 12 patients [42%] versus 10 of 11 patients [91%], respectively, p = 0.027). Logistic regression analysis showed that use of beta-lactam antibiotics as initial intravenous empirical therapy was a significant independent risk factor predicting implant failure.
Conclusion: The rate of implant retention was lower in patients administered beta-lactam antibiotics as initial intravenous empirical treatment.
Keywords
knee, infection, treatment, joint replacement, debridement, antibiotics, irrigation, and retention
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Sachiyuki Tsukada
Hokusuikai Kinen Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1186-5232
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 27 Jan, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Orthopedics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Beta-lactam antibiotics are frequently selected as initial intravenous empirical therapy in acute periprosthetic joint infection (PJI), but show poor drug migration to the knee joint.
Methods: We retrospectively assessed 23 patients undergoing irrigation and debridement surgery for acute PJI after primary TKA. First, we compared the success rate of implant retention between patients receiving beta-lactam antibiotics as initial intravenous empirical therapy and those receiving antibiotics other than beta-lactams. Second, multivariate logistic regression analysis was used to control for confounding factors and to distinguish independent risk factors for the failure of implant retention.
Results: Twelve patients received beta-lactam antibiotics as initial intravenous therapy (67% received cefazolin) and 11 patients received antibiotics other than beta-lactams (82% received linezolid). Patients receiving beta-lactam antibiotics had significantly lower implant retention rate than those receiving other antibiotics (5 of 12 patients [42%] versus 10 of 11 patients [91%], respectively, p = 0.027). Logistic regression analysis showed that use of beta-lactam antibiotics as initial intravenous empirical therapy was a significant independent risk factor predicting implant failure.
Conclusion: The rate of implant retention was lower in patients administered beta-lactam antibiotics as initial intravenous empirical treatment.
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