SARS-CoV-2 BA.1 and BA.2 co-infection detected by genomic surveillance in Brazil, January 2022

doi:10.21203/rs.3.rs-1547203/v1

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SARS-CoV-2 BA.1 and BA.2 co-infection detected by genomic surveillance in Brazil, January 2022

https://doi.org/10.21203/rs.3.rs-1547203/v1

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In January 2022, the genomic surveillance of DASA laboratories identified a SARS-CoV-2 BA.1 and BA.2 co-infection in a sample from a patient resident in Brazil. The bioinformatics protocols using Dragen^TM Covid Lineage App do not allow the detection of recombinants or mixed-infections. Therefore, the number of co-infections is certainly underestimated.

Funding

This study was partially financed by KFW DEG Bank, grant G0512.

World Health Organization Tracking SARS-CoV-2 variants
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Table: Percentage of bases in key positions of the spike gene able to discriminate between SARS-CoV-2 BA.1 and SARS CoV-2 BA.2

SARS-CoV-2 lineage	Mutation	Nucleotide Position	Nucleotide (%)
BA.2	‍T19I	21,618	C (69), T (28)
BA.1	A67V	21,762	T (56), C (43)
BA.1	T95I	21,846	T (66), C (33)
BA.2	V213G	22,200	G (93), T (7)
BA.2	T376A	22,688	G (95), A (4)
BA.2	D405N	22,775	A (96), G (3)
BA.2	R408S	22,786	C (96), A (4)
BA.1	G496S	23,048	A (71), G (26)
BA.1	T547K	23,202	A (58), C (41)
BA.1	N856K	24,130	A (64), C (35)
BA.1	L981F	24,503	T (68), C (32)

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Reviews received at journal
14 Apr, 2022
Reviewers invited by journal
14 Apr, 2022
Editor assigned by journal
12 Apr, 2022
First submitted to journal
11 Apr, 2022

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SARS-CoV-2 BA.1 and BA.2 co-infection detected by genomic surveillance in Brazil, January 2022

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