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Research Article
Rong Zhou
West China Second University Hospital of Sichuan University
Corresponding Author
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The changing family planning policy from One-Child to Two-Child Policy, led to a significant increase in the proportion of pregnancies with variant interpregnancy intervals (IPIs) after previous cesarean section (CS). To examine the relationship between IPI and perinatal outcomes, we conducted a retrospective cohort study of 1854 women having a history of CS and delivered in 2016 at West China Second University Hospital. With an IPI of 24-59 months as the reference, the associations between various IPIs (<24, 60-119, and ≥120 months) and pregnancy outcomes were examined by multivariate logistic regression analysis with multiple models. We found that IPI <24 months significantly increased the risk of anemia in late pregnancy (aOR 2.09, 95% CI 1.21-2.62, p = 0.008). IPI <24 months was associated with a higher risk for incomplete uterine rupture (OR 1.30, 95% CI 1.05-1.61), IPI ≥60 months was related to a lower risk for incomplete uterine rupture (IPI = 60-119 months: OR 0.77, 95% CI 0.62-0.95; IPI ≥120 months, OR 0.59, 95% CI 0.38-1.08), and women with IPI ≥120 months were more likely to develop gestational hypertension (GHP) (p = 0.036) and gestational diabetes mellitus (GDM) (p = 0.001). These effects became nonsignificant after adjusting possible confounders. This study revealed that IPI may combine with other factors to affect GHP, GDM, and uterine rupture in the subsequent pregnancy after previous CS.
Keywords
family planning policy, Two-Child Policy, gestational diabetes mellitus (GDM), cesarean section (CS)
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No competing interests reported.
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Rong Zhou
West China Second University Hospital of Sichuan University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 01 Feb, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The changing family planning policy from One-Child to Two-Child Policy, led to a significant increase in the proportion of pregnancies with variant interpregnancy intervals (IPIs) after previous cesarean section (CS). To examine the relationship between IPI and perinatal outcomes, we conducted a retrospective cohort study of 1854 women having a history of CS and delivered in 2016 at West China Second University Hospital. With an IPI of 24-59 months as the reference, the associations between various IPIs (<24, 60-119, and ≥120 months) and pregnancy outcomes were examined by multivariate logistic regression analysis with multiple models. We found that IPI <24 months significantly increased the risk of anemia in late pregnancy (aOR 2.09, 95% CI 1.21-2.62, p = 0.008). IPI <24 months was associated with a higher risk for incomplete uterine rupture (OR 1.30, 95% CI 1.05-1.61), IPI ≥60 months was related to a lower risk for incomplete uterine rupture (IPI = 60-119 months: OR 0.77, 95% CI 0.62-0.95; IPI ≥120 months, OR 0.59, 95% CI 0.38-1.08), and women with IPI ≥120 months were more likely to develop gestational hypertension (GHP) (p = 0.036) and gestational diabetes mellitus (GDM) (p = 0.001). These effects became nonsignificant after adjusting possible confounders. This study revealed that IPI may combine with other factors to affect GHP, GDM, and uterine rupture in the subsequent pregnancy after previous CS.
Figure 1
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
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