Background : Platelet-rich plasma (PRP) is an autologous, self-blood product, anticoagulated blood product generated by centrifugation method of whole blood that primarily contains platelets at amounts up to 5 times those found in physiologic platelet concentrations. PRP contains multiple growth factors such as transforming growth factor (TGF), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and insulin-like growth factor-1 within the alpha granules of platelets (IGF-1). Platelets also contain antibacterial and fungicidal proteins, metalloproteinases, coagulation factors, and membrane glycoproteins, which can regulate inflammation by promoting the production of various integrins, interleukins, and chemokines. Pelvic organ prolapse occurs when the genitalia organ, bladder, rectum, and intestine protrude into the vaginal canal or even out of it due to the weakening of ligaments and muscles that serve as suspensors for the pelvic organs. Surgery is one of the treatment options for pelvic organ prolapse. The use of platelet rich plasma in pelvic organ prolapse surgery is becoming much more common. The goal of this procedure is to reconstruct the anatomical components of the pelvic supporting tissues and increase the healing process. To determine the efficacy of PRP on pelvic organ prolapse surgery, we will synthesize the available research on the use of platelet rich plasma for pelvic organ prolapse surgery. The goal of this study is to conduct a scoping study of the published research on the efficacy of platelet rich plasma for the surgery procedure of female pelvic organ prolapse.
Methods/design : This review was conducted on research articles in PubMed, Proquest, EBSCO, ScienceDirect databases published between January 2010 – Desember 2021 regarding the use of platelet rich plasma for pelvic organ prolapse surgery. All primary research in human, case reports and case series will be included to evaluate the outcome of platelet rich plasma as an adjunct to conventional surgery in the treatment of pelvic organ prolapse.
Discussion : This review will offer actual evidence of PRP's efficacy for pelvic organ prolapse surgery. This is a new approach, and the findings of this study are expected to inform clinical practice and ongoing research focused on improving outcome of pelvic organ prolapse surgery.
Trial registration number : osf.io/gyr72