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Dawei Gao
Yanshan University
Corresponding Author
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Owing to deficiency of lymphatic reflux in the tumor, the retention of tumor interstitial fluid causes the aggravation of tumor interstitial pressure (TIP), which leads to unsatisfactory tumor penetration of nanomedicine. It is the main inducement of tumor recurrence and metastasis. Herein, we design a pyroelectric catalysis-based “Nano-lymphatic” to decrease the TIP for enhanced tumor penetration and treatments. It realizes photothermal therapy and decomposition of tumor interstitial fluid under NIR-II laser irradiation after reaching the tumor, which reduces the TIP for enhanced tumor penetration. Simultaneously, reactive oxygen species generated during the pyroelectric catalysis can further damage deep tumor stem cells. The results indicate that the “Nano-lymphatic” relieves 52% of TIP, leading to enhanced tumor penetration, which effectively inhibits the tumor proliferation (93.75%) and recurrence. Our finding presents a novel strategy to reduce TIP by pyroelectric catalysis for enhanced tumor penetration and improved treatments, which is of great significance for drug delivery.
Keywords
Tumor interstitial pressure, Nano-lymphatic, Pyroelectric catalysis, Enhanced tumor penetration, Hydrodynamic therapy
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There is NO Competing Interest.
This is a list of supplementary files associated with this preprint. Click to download.
- SupplementaryInformation.docx
Supplementary Informaton
- Scheme1.pdf
Scheme 1. Illustration of the “Nano-lymphatic” (M/CdS-HA) synthesis and decrease of TIP by pyroelectric catalysis for enhanced tumor penetration, PTT, and “Hydrodynamic therapy”.
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Article
Dawei Gao
Yanshan University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 04 Feb, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Owing to deficiency of lymphatic reflux in the tumor, the retention of tumor interstitial fluid causes the aggravation of tumor interstitial pressure (TIP), which leads to unsatisfactory tumor penetration of nanomedicine. It is the main inducement of tumor recurrence and metastasis. Herein, we design a pyroelectric catalysis-based “Nano-lymphatic” to decrease the TIP for enhanced tumor penetration and treatments. It realizes photothermal therapy and decomposition of tumor interstitial fluid under NIR-II laser irradiation after reaching the tumor, which reduces the TIP for enhanced tumor penetration. Simultaneously, reactive oxygen species generated during the pyroelectric catalysis can further damage deep tumor stem cells. The results indicate that the “Nano-lymphatic” relieves 52% of TIP, leading to enhanced tumor penetration, which effectively inhibits the tumor proliferation (93.75%) and recurrence. Our finding presents a novel strategy to reduce TIP by pyroelectric catalysis for enhanced tumor penetration and improved treatments, which is of great significance for drug delivery.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
There is NO Competing Interest.
This is a list of supplementary files associated with this preprint. Click to download.
- SupplementaryInformation.docx
Supplementary Informaton
- Scheme1.pdf
Scheme 1. Illustration of the “Nano-lymphatic” (M/CdS-HA) synthesis and decrease of TIP by pyroelectric catalysis for enhanced tumor penetration, PTT, and “Hydrodynamic therapy”.
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