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Case report
Majocchi’s Granuloma on the Forearm Caused by Trichophyton tonsurans in an Immunocompetent Patient
Ru-zhi Zhang
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at Annals of Clinical Microbiology and Antimicrobials.
Majocchi's granuloma is an uncommon fungal infection of the dermis and subcutaneous tissue. The most frequently identified cause of Majocchi’s granuloma is anthropophilic Trichophyton rubrum, and it is most commonly located on the anterior aspect of the lower limbs in women. Here, we report a case of Majocchi’s granuloma on the forearm, a site that is rarely involved, in a 62-year-old woman who had been bitten by a dog. Histological examination revealed a dense dermal infiltrate composed of lymphoplasmacytic cells and neutrophils, with hyphae in the dermis. The presence of the fungus, Trichophyton tonsurans, was confirmed by mycological examination and molecular methods. Therefore, histological and mycological examination confirmed the diagnosis of Majocchi’s granuloma. The patient was treated with local moxibustion and itraconazole, 200 mg/day, for 60 days, which facilitated a complete resolution of the lesions.
Keywords
Majocchi’s granuloma, Trichophyton tonsurans, Itraconazole, Forearm
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CURRENT STATUS: Published
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Posted 13 Aug, 2020
Published
On 02 Sep, 2020
No community comments so far
Editorial decision: Accept
On 24 Aug, 2020
Review #2 received
Received 20 Aug, 2020
Reviewer #2 agreed
On 12 Aug, 2020
Review #1 received
Received 10 Aug, 2020
Reviewer #1 agreed
On 06 Aug, 2020
Editor assigned
On 05 Aug, 2020
Reviewers invited
Invitations sent on 05 Aug, 2020
Submission checks complete
On 04 Aug, 2020
Editor invited
On 04 Aug, 2020
No comments provided
Review #1 received
Received 21 Jul, 2020
Editorial decision: Major revision
On 21 Jul, 2020
Review #2 received
Received 15 Jul, 2020
Reviewer #2 agreed
On 12 Jul, 2020
Reviewer #1 agreed
On 10 Jul, 2020
Reviewers invited
Invitations sent on 23 Jun, 2020
Editor assigned
On 12 Mar, 2020
Submission checks complete
On 11 Mar, 2020
Editor invited
On 11 Mar, 2020
No comments provided
Editorial decision: Revise before peer review
On 02 Mar, 2020
Editor assigned
On 28 Feb, 2020
Submission checks complete
On 27 Feb, 2020
Editor invited
On 27 Feb, 2020
First submitted
On 26 Feb, 2020
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Subject Areas
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This preprint is under consideration at Annals of Clinical Microbiology and Antimicrobials. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Case report
Majocchi’s Granuloma on the Forearm Caused by Trichophyton tonsurans in an Immunocompetent Patient
Ru-zhi Zhang
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 3
Posted 13 Aug, 2020
Published
On 02 Sep, 2020
No community comments so far
Editorial decision: Accept
On 24 Aug, 2020
Review #2 received
Received 20 Aug, 2020
Reviewer #2 agreed
On 12 Aug, 2020
Review #1 received
Received 10 Aug, 2020
Reviewer #1 agreed
On 06 Aug, 2020
Editor assigned
On 05 Aug, 2020
Reviewers invited
Invitations sent on 05 Aug, 2020
Submission checks complete
On 04 Aug, 2020
Editor invited
On 04 Aug, 2020
No comments provided
Review #1 received
Received 21 Jul, 2020
Editorial decision: Major revision
On 21 Jul, 2020
Review #2 received
Received 15 Jul, 2020
Reviewer #2 agreed
On 12 Jul, 2020
Reviewer #1 agreed
On 10 Jul, 2020
Reviewers invited
Invitations sent on 23 Jun, 2020
Editor assigned
On 12 Mar, 2020
Submission checks complete
On 11 Mar, 2020
Editor invited
On 11 Mar, 2020
No comments provided
Editorial decision: Revise before peer review
On 02 Mar, 2020
Editor assigned
On 28 Feb, 2020
Submission checks complete
On 27 Feb, 2020
Editor invited
On 27 Feb, 2020
First submitted
On 26 Feb, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
General Microbiology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at Annals of Clinical Microbiology and Antimicrobials.
Majocchi's granuloma is an uncommon fungal infection of the dermis and subcutaneous tissue. The most frequently identified cause of Majocchi’s granuloma is anthropophilic Trichophyton rubrum, and it is most commonly located on the anterior aspect of the lower limbs in women. Here, we report a case of Majocchi’s granuloma on the forearm, a site that is rarely involved, in a 62-year-old woman who had been bitten by a dog. Histological examination revealed a dense dermal infiltrate composed of lymphoplasmacytic cells and neutrophils, with hyphae in the dermis. The presence of the fungus, Trichophyton tonsurans, was confirmed by mycological examination and molecular methods. Therefore, histological and mycological examination confirmed the diagnosis of Majocchi’s granuloma. The patient was treated with local moxibustion and itraconazole, 200 mg/day, for 60 days, which facilitated a complete resolution of the lesions.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5