There have been several reports of thrombotic adverse events after administration of the mRNA COVID vaccine  . The onset of autoimmune disease has also been reported following viral illness as well as following vaccination . The antiphospholipid syndrome is an autoimmune hypercoagulable state that can result in thrombotic events such as deep venous thrombosis, pulmonary embolus, and stroke . The antiphospholipid syndrome has also been reported following natural Covid infection . Herein we present a case of “antiphospholipid syndrome” following COVID mRNA vaccination and associated with life threatening thrombosis.