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Chen Yun
Peking University
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Background: Depression is a well-known mood disorder characterized by persistently low mood and loss of interest and a feeling of sadness. Plants and plant-derived agents have recently attracted the interest of researchers for their therapeutic effects against several illnesses, including mental disorders, and several herbal plants and herbal formulations are useful against experimental depression. In this study, the neuroprotective effects of Hedyotis corymbosa extract were investigated in rats induced with chronic mild stress.
Methods: Animals were designated into the following groups: control, 0, 150, and 300 mg of extracts. The dose was given for 30 consecutive days via the oral route. Sucrose preference analysis, forced swim, and open field tests were performed, and serum cortisol and monoamine levels in brain tissue were determined. Expression of brain-derived neurotrophic factor (BDNF) was also examined.
Results: Supplementation with extract increased the sucrose preference ratio, locomotor activity, and monoamines and decreased serum cortisol levels. The protein and mRNA expression of BDNF in the brain tissue was decreased by 62.58% and 73% in control rats. However, supplementation with extracts significantly increased BDNF mRNA expression (by 107% and 229.6% in groups 150 mg and 300 mg, respectively). Similarly, the protein expression of BDNF increased by 82.3% and 141.2% in groups 150 mg and 300 mg, respectively.
Conclusion: In summary, experimental results suggest that supplementation with extracts of Hedyotis corymbosa may be effective against depression.
Keywords
Antidepressant, Hedyotis corymbosa, rat, stress, sucrose
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Chen Yun
Peking University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 03 Mar, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Psychiatry
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Depression is a well-known mood disorder characterized by persistently low mood and loss of interest and a feeling of sadness. Plants and plant-derived agents have recently attracted the interest of researchers for their therapeutic effects against several illnesses, including mental disorders, and several herbal plants and herbal formulations are useful against experimental depression. In this study, the neuroprotective effects of Hedyotis corymbosa extract were investigated in rats induced with chronic mild stress.
Methods: Animals were designated into the following groups: control, 0, 150, and 300 mg of extracts. The dose was given for 30 consecutive days via the oral route. Sucrose preference analysis, forced swim, and open field tests were performed, and serum cortisol and monoamine levels in brain tissue were determined. Expression of brain-derived neurotrophic factor (BDNF) was also examined.
Results: Supplementation with extract increased the sucrose preference ratio, locomotor activity, and monoamines and decreased serum cortisol levels. The protein and mRNA expression of BDNF in the brain tissue was decreased by 62.58% and 73% in control rats. However, supplementation with extracts significantly increased BDNF mRNA expression (by 107% and 229.6% in groups 150 mg and 300 mg, respectively). Similarly, the protein expression of BDNF increased by 82.3% and 141.2% in groups 150 mg and 300 mg, respectively.
Conclusion: In summary, experimental results suggest that supplementation with extracts of Hedyotis corymbosa may be effective against depression.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
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