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Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study
Yun-Ai Su
Peking University Sixth Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0001-8445-9633
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Psychiatry.
Background: Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients.
Methods: One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I.). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured.
Results: Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients.
Conclusion: Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.
Keywords
Uric acid, Suicide risk, Major depressive disorder, female
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CURRENT STATUS: Published
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On 19 Sep, 2020
Editorial decision: Minor revision
On 18 Sep, 2020
Version 2
Posted 12 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 14 Sep, 2020
Review #2 received
Received 13 Sep, 2020
Reviewer #2 agreed
On 14 Aug, 2020
Reviewer #1 agreed
On 12 Aug, 2020
Review #1 received
Received 12 Aug, 2020
Reviewers invited
Invitations sent on 11 Aug, 2020
Editor assigned
On 06 Aug, 2020
Submission checks complete
On 05 Aug, 2020
Editor invited
On 05 Aug, 2020
No comments provided
Editorial decision: Major revision
On 23 Jun, 2020
Review #2 received
Received 20 Jun, 2020
Reviewer #2 agreed
On 13 Apr, 2020
Review #1 received
Received 27 Feb, 2020
Reviewer #1 agreed
On 13 Feb, 2020
Reviewers invited
Invitations sent on 10 Dec, 2019
Editor assigned
On 21 Nov, 2019
First submitted
On 20 Nov, 2019
Submission checks complete
On 20 Nov, 2019
Editor invited
On 20 Nov, 2019
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Subject Areas
Psychiatry
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This preprint is under consideration at BMC Psychiatry. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study
Yun-Ai Su
Peking University Sixth Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0001-8445-9633
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
No comments provided
Submission checks complete
On 19 Sep, 2020
Editorial decision: Minor revision
On 18 Sep, 2020
Version 2
Posted 12 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 14 Sep, 2020
Review #2 received
Received 13 Sep, 2020
Reviewer #2 agreed
On 14 Aug, 2020
Reviewer #1 agreed
On 12 Aug, 2020
Review #1 received
Received 12 Aug, 2020
Reviewers invited
Invitations sent on 11 Aug, 2020
Editor assigned
On 06 Aug, 2020
Submission checks complete
On 05 Aug, 2020
Editor invited
On 05 Aug, 2020
No comments provided
Editorial decision: Major revision
On 23 Jun, 2020
Review #2 received
Received 20 Jun, 2020
Reviewer #2 agreed
On 13 Apr, 2020
Review #1 received
Received 27 Feb, 2020
Reviewer #1 agreed
On 13 Feb, 2020
Reviewers invited
Invitations sent on 10 Dec, 2019
Editor assigned
On 21 Nov, 2019
First submitted
On 20 Nov, 2019
Submission checks complete
On 20 Nov, 2019
Editor invited
On 20 Nov, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Psychiatry
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Psychiatry.
Background: Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients.
Methods: One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I.). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured.
Results: Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients.
Conclusion: Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.