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Peng Yang
The First Affiliated Hospital of Anhui Medical University
Corresponding Author
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Background: Pituitary tumor transforming genes (PTTG1, PTTG2 and PTTG3P) play a key role in the pathogenesis and development of human cancers. Studies show that overexpression of the PTTG genes is associated with tumor progression and migration. However, little is known about the function of the PTTG genes in the prognostic value of renal clear cell carcinoma (KIRC).
Methods: the expression and survival data for KIRC patients were mined from ONCOMINE, UALCAN, Human Protein Atlas, TCGAportal, GEPIA2, Metascape，cBioPortal databases and STRING.
Results: PTTG1, 2, and 3P mRNA and protein expression was upregulated in KIRC patients compared to normal tissues, and higher expression levels of PTTG family genes were associated with shorter overall survival (OS). what's more, overexpression of the PTTG family genes has been found to correlate with individual cancer stages and pathological tumor grades. In addition, 18% of mutations in the PTTG family genes were associated with short-term survival in patients with KIRC
Conclusions: we found that a single PTTG genes or PTTG family genes as a whole may be a potential prognostic biomarker for KIRC.
Keywords
PTTG, KIRC, prognostic, biomarker
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See the published version of this preprint at World Journal of Surgical Oncology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Peng Yang
The First Affiliated Hospital of Anhui Medical University
Corresponding Author
Badges
Prescreen
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Complete author information
Appropriate declaration statements
Potential risks to human health
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Peer Review Timeline
CURRENT STATUS: Published
View the published article at World Journal of Surgical Oncology.
Version 1
Posted 03 Feb, 2021
No community comments so far
Review #14 received
Received 07 Feb, 2021
Review #3 received
Received 07 Feb, 2021
Review #7 received
Received 07 Feb, 2021
Reviewer #15 agreed
On 05 Feb, 2021
Review #15 received
Received 05 Feb, 2021
Review #5 received
Received 04 Feb, 2021
Reviewer #14 agreed
On 04 Feb, 2021
Review #11 received
Received 04 Feb, 2021
Reviewer #6 agreed
On 03 Feb, 2021
Reviewer #7 agreed
On 03 Feb, 2021
Reviewer #8 agreed
On 03 Feb, 2021
Reviewer #9 agreed
On 03 Feb, 2021
Reviewer #10 agreed
On 03 Feb, 2021
Reviewer #11 agreed
On 03 Feb, 2021
Reviewer #12 agreed
On 03 Feb, 2021
Reviewer #13 agreed
On 03 Feb, 2021
Review #8 received
Received 03 Feb, 2021
Reviewer #5 agreed
On 03 Feb, 2021
Review #6 received
Received 03 Feb, 2021
Reviewer #3 agreed
On 01 Feb, 2021
Reviewer #4 agreed
On 01 Feb, 2021
Reviews received
Received 01 Feb, 2021
Reviewer #2 agreed
On 01 Feb, 2021
Review #1 received
Received 01 Feb, 2021
Editor assigned
On 31 Jan, 2021
Reviewers invited
Invitations sent on 31 Jan, 2021
Reviewer #1 agreed
On 31 Jan, 2021
Editor invited
On 31 Jan, 2021
Submission checks complete
On 31 Jan, 2021
First submitted
On 20 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at World Journal of Surgical Oncology.
Background: Pituitary tumor transforming genes (PTTG1, PTTG2 and PTTG3P) play a key role in the pathogenesis and development of human cancers. Studies show that overexpression of the PTTG genes is associated with tumor progression and migration. However, little is known about the function of the PTTG genes in the prognostic value of renal clear cell carcinoma (KIRC).
Methods: the expression and survival data for KIRC patients were mined from ONCOMINE, UALCAN, Human Protein Atlas, TCGAportal, GEPIA2, Metascape，cBioPortal databases and STRING.
Results: PTTG1, 2, and 3P mRNA and protein expression was upregulated in KIRC patients compared to normal tissues, and higher expression levels of PTTG family genes were associated with shorter overall survival (OS). what's more, overexpression of the PTTG family genes has been found to correlate with individual cancer stages and pathological tumor grades. In addition, 18% of mutations in the PTTG family genes were associated with short-term survival in patients with KIRC
Conclusions: we found that a single PTTG genes or PTTG family genes as a whole may be a potential prognostic biomarker for KIRC.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
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