Full neuroendoscopic contralateral longitudinal fissure approach to resection of parafalcine meningioma via falx cerebri – Retractorless surgical technique: case report

doi:10.21203/rs.3.rs-1597356/v1

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Case Report

Full neuroendoscopic contralateral longitudinal fissure approach to resection of parafalcine meningioma via falx cerebri – Retractorless surgical technique: case report

https://doi.org/10.21203/rs.3.rs-1597356/v1

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Background: We reported one case of parafalcine meningioma, using a full neuroendoscopic contralateral longitudinal fissure approach to completely resect meningioma through the falx cerebri.

Case presentation: This case was a 50-year-old female with a right anterior cerebral parafalcine meningioma. Her left limbs had decreased sensations of temperature, tactile and pain than the right side, muscle strength was grade IV, and Babinski sign was positive on the left. CT and MRI showed a mass on the right frontoparietal with edema.

The patient was in supine position and the head was rotated 20 degrees to the opposite side. A neuronavigation was employed to perform a precise surface localization of parafalcine meningioma. Under neuroendoscopy, a contralateral craniotomy and a longitudinal fissure approach were followed by an incision of dura to expose arachnoid, then arachnoid was separated until falx cerebri along its surface. Neuronavigation was employed again to precisely locate the projection of meningioma in the contralateral falx cerebri. According to the position, firstly removed the invaded falx cerebri, blocked the blood supply of the meningioma, then completely resected the meningioma without retraction of normal brain tissue.

Conclusion: This report explored a full neuroendoscopic contralateral longitudinal fissure approach to complete resect parafalcine meningioma via falx cerebri using retractorless surgical technique. This approach can reduce the retraction of normal brain tissue to enhance protection of brain function, while maximizing the total resection rate of parafalcine meningioma.

Parafalcine Meningioma

Full Endoscopic Surgery

Contralateral Longitudinal Fissure Approach

Retractorless Surgical Technique

Parafalcine meningioma refers to a common type of meningioma located in the longitudinal fissure and is connected to falx cerebri. Except its large growing space and plaque-like growth, parafalcine meningioma is barely involved in the superior sagittal sinus. It often invades into contralateral hemisphere, and sometimes it can develop to both sides[1]. An ipsilateral craniotomy is generally performed for the surgical resection of parafalcine meningioma. Along the longitudinal fissure, the cortical area without bridge veins is selected, and the cerebral hemisphere is retracted from the falx cerebri by a retractor under the microscope. The tumor is gradually explored until it is reached. The tumor is first devascularized, then separated and finally dissected from the falx cerebri[2]. However, after years of clinical practice, it is found that an improper use or an over-reliance of brain automatic retractor to retract the ipsilateral cerebral hemisphere may lead to ipsilateral postoperative cerebral edema, and further lead to the contralateral limb paralysis, sensory disturbance, and visual field deficits[3]. With the rapid development of neuroendoscopy in recent years, we have explored the application of full endoscopic contralateral longitudinal fissure approach via the falx cerebri to remove parafalcine meningiomas without retractor. The case is now reported as follows:

Female, 50 years old, married. Han Chinese, farmer. The patient was admitted to hospital in August and her chief complaint was numbness of the left lower extremity. The patient reported that there was no obvious cause for the numbness and stiff in the left upper extremity before August. Afterwards, she started to feel numbness in her left lower extremity, but no syndromes of headache, dizziness, or facial palsy. She was admitted in a local hospital. CT and MRI scan showed a tumor on the right frontoparietal with edema (Fig. 1). Physical examination: Her left limbs had milder sensations of temperature, tactile and pain than the right side, muscle strength was grade IV, and Babinski sign was positive on the left. Diagnosis of administration: parafalcine meningioma on the right frontoparietal.

Surgical Treatment: The patient underwent general anesthesia. A full endoscopic left longitudinal fissure approach was employed to resect right parafalcine meningioma. After the head frame was fixed, the head was rotated 30° toward front, which exposed the operation area on the frontoparietal. At the same time, the head was rotated 15–20° toward to the left side, allowing the gravity retracted the brain tissue in front lobe towards the left side. This method can expose more natural cavity of the longitudinal fissure and allow endoscopy entering the cavity. Upon the retractorless technique, the left falx cerebri was exposed to perform the devascularization of right parafalcine meningioma. Tumor debulking was operated first to reduce the tumor size, then tumor was separated from the arachnoid of right frontoparietal and finally resected. After the operation, the patient had a transient right limbs numbness with weak muscle strength (Grade IV). One week after the operation, the muscle strength of bilateral limbs was completely recovered (Grade V). Postoperative CT and MRI confirmed a complete resection of the tumor (Fig. 2.).

Parafalcine meningioma is difficult to expose due to its deep location in the cerebral longitudinal fissure. Generally, the ipsilateral craniotomy is performed. Under the microscope, the cerebral hemisphere is retracted from the falx cerebri by a brain retractor. The tumor base is first devascularized and then dissected from the surrounding cerebral structures. After tumor is completely removed, the base on the falx cerebri is electrocauterized[4, 5]. However, this approach has its limitations: 1. The meningioma is deeply buried in the ipsilateral cerebral longitudinal fissure. It requires a use of brain retractor to retract hemisphere from the falx cerebri. This operation may lead to postoperative intracerebral hematoma and injury, retractor-induced edema, or ischemic injury due to retractor-induced decrease in cerebral blood perfusion resulting from a direct compression to the cortex and subcortical tissues[6]. 2. The tumor has to be devascularized at its base. Debulking and devascularization has to be done at the same time due to the block from tumor itself, which easily lead to the excessive blood loss and is not conducive to postoperative recovery. In some cases, sometimes, it is even required to remove the brain tissues in frontal or occipital lobes to expose tumor[7].

Soumya Mukherjee reported the resection of a parafalcine meningioma from the contralateral longitudinal fissure approach under the microscope. It can avoid the retraction of cortex to expose tumor and reduce the retraction-induced brain injury and edema. At the same time, it can expose the falx first to facilitate the devascularization of meningioma[8]. However, it is still required to retract the brain tissue using retractor to expose the lateral fissure for surgery, which cannot achieve a complete retractorless. Thus, it may still lead to retractor-induced edema, or a direct compression to the cortex and subcortical tissues.

The rapid development of neuroendoscopy in recent years has provided us a basis for exploring the resection of parafalcine meningioma without a retractor. The surgical position is rotated 15–20° to the opposite side, and the contralateral cerebral lobe is collapsed laterally by gravity, so that the natural cavity of the longitudinal fissure is exposed as wide as possible. The endoscope can be directly inserted into the longitudinal fissure and reach the lower boundary of the falx cerebri- the lower sagittal sinus -without any brain retractor to facilitate the exposure of the longitudinal fissure. When the operation begins to excise the falx cerebri, the endoscopic close observation and multi-angle observation are used to assist the tumor devascularization from any part of contralateral falx cerebri without any retractor. The falx cerebri can be more widely exposed and excised to achieve SIMPSON Grade I resection and reduce recurrence. When separate the arachnoid between the tumor and the surrounding normal brain tissues, the ipsilateral approach is vertical to the tumor boundary, while the contralateral approach enters at an oblique angle that reduces the retraction of brain tissues. Combining endoscopic close- and multi-angle observations, the contralateral approach can completely separate the arachnoid between tumor and surrounding normal brain tissues and reduce the retraction-induced brain edema and injury (Fig. 3). In addition, in this case, the ipsilateral brain surface has a thick drainage vein, which also increases the difficulty of ipsilateral approach. Once the drainage vein of the functional area is damaged, it is easy to cause severe postoperative dysfunction or even unrecoverable dysfunction. Moreover, in this case, arachnoid cysts were observed on the contralateral side and the cerebral cortex was significantly lower than the contralateral side, which also created conditions for the contralateral approach. In our another case, we observed the contralateral arachnoid cyst and the significantly lower cortex. Whether the contralateral arachnoid cysts are accidental events or patterns remains unknown and it needs further studies.

This case of complete resection of parafalcine meningiomas was completely under neuroendoscopy, and used the retractorless technique and a contralateral longitudinal fissure approach via falx cerebri. There was no obvious brain injury or intracerebral hematoma, which reduced postoperative complications caused by retraction. The development of modern neuroendoscopy technology, using its slimness, closed observation and multi-angle observation, can maximally enhance the advantages of retractorless surgical technique, and provide a minimally invasive surgical method for surgical resection of parafalcine meningioma.

CT, Computed Tomography; MRI, Magnetic Resonance Imaging

Acknowledgements

We thank the valuable assistance in the care of this patient provided by the oncological neurosurgery services at Shanxi Provincial People's Hospital, Shanxi Medical University in the care of this patient. We also thank Dr. Wenya Linda Bi of Harvard Medical School for critical reading of the manuscript.

Authors’ contributions

Conception and design: CH. Acquisition of data: ML and YZ. Analysis and interpretation of data: ML, YZ, JL, KW, PL and HL. Drafting the article: all authors. Critically revising the article: all authors. Reviewed submitted version of manuscript: all authors. Approved the final version of the manuscript on behalf of all authors: CH. Statistical analysis: HJ and SZ. Administrative / technical / material support: SC, GZ and JZ. Study supervision: CH.

Funding

National Natural Science Foundation of China (30901774); Natural Science Foundation of Shanxi Province (2014011038-2); Shanxi Province Science and Technology Development Plan (Social Development Section) (20140313011-5); Key R&D Plan of Shanxi Province (International Cooperation Project) (201803D421055); Shanxi Province Overseas Students Science and Technology Activities Selection Funding Project (2018014); Scientific research projects with provincial special funds in Shanxi Provincial people's Hospital (sj20019003); Fundamental Research Program of Shanxi Province(20210302123352); Shanxi Province Health Commission Scientific Research Project(2022052)

Availability of data and materials

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

Ethics approval and consent to participate

The patient provides informed consent, which was registered in the medical record.

Consent for publication

Written informed consents were obtained from the patients for publication of this case report and any accompanying images. A copy of the written consent is available for review by the editor of this journal.

Competing interests

The authors declare that they have no competing interests.

Author details

¹ Department of Neurosurgery, Shanxi Provincial People's Hospital, Shanxi Medical University, No. 29 Shuangta Road, Taiyuan, 030012, China.

² Department of Neurosurgery, Shuozhou People's hospital, Shanyang Street No. 263, Shuozhou, 036000, China.

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No competing interests reported.

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Full neuroendoscopic contralateral longitudinal fissure approach to resection of parafalcine meningioma via falx cerebri – Retractorless surgical technique: case report

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