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Márcio Schneider Medeiros
Hospital de Clinicas de Porto Alegre
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4248-2277
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Background Multiple studies have suggested that various pesticides are associated with a higher risk of developing Parkinson’s disease (PD) and may influence the progression of the disease. This study examines whether pesticide exposure influences the risk of mortality among patients with PD in Southern Brazil, when accounting for socioeconomic status, nicotine exposure, and caffeine exposure.
Methods 150 patients with idiopathic PD were enrolled from 2008-2013 and followed until 2019. In addition to undergoing a detailed neurologic evaluation, patients completed surveys regarding socioeconomic status and environmental exposures.
Results Twenty patients (13.3%) reported a history of occupational pesticide exposure with a median duration of exposure of 10 years (mean = 13.1, SD = 11.2). Patients with a history of occupational pesticide exposure had higher UPDRS-III scores, though there were no significant differences in regards to age, sex, disease duration, Charlson Comorbidity Index, and age at symptom onset. Patients with occupational pesticide exposure were more than twice as likely to die than their unexposed PD counterparts (HR = 2.32, 95% CI [1.15, 4.66], p = 0.22). Occupational pesticide exposure was also a significant predictor of death in a cox-proportional hazards model which included smoking and caffeine intake history and another which included several measures of socioeconomic status.
Conclusion In this prospective cohort study, we found an increased all-cause mortality risk in PD patients with occupational exposure to pesticides. More studies are needed to further analyze this topic with longer follow-up periods, more detailed exposure information, and more specific causes of mortality.
Keywords
pesticides, Parkinson, mortality, occupational exposure, environmental exposure
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CURRENT STATUS: Published
View the published article at Environmental Health.
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Editorial decision: Accept
On 06 Jun, 2020
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On 05 Jun, 2020
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On 04 Jun, 2020
Editor invited
On 04 Jun, 2020
No comments provided
Editorial decision: Minor revision
On 14 May, 2020
Review #2 received
Received 09 May, 2020
Reviewer #2 agreed
On 24 Apr, 2020
Reviewer #1 agreed
On 23 Apr, 2020
Review #1 received
Received 23 Apr, 2020
Reviewers invited
Invitations sent on 21 Apr, 2020
Editor assigned
On 20 Apr, 2020
Submission checks complete
On 19 Apr, 2020
Editor invited
On 19 Apr, 2020
Version 1
Posted 05 Mar, 2020
No comments provided
Editorial decision: Major revision
On 19 Mar, 2020
Review #2 received
Received 18 Mar, 2020
Reviewer #2 agreed
On 13 Mar, 2020
Review #1 received
Received 12 Mar, 2020
Reviewer #1 agreed
On 03 Mar, 2020
Editor assigned
On 28 Feb, 2020
Reviewers invited
Invitations sent on 28 Feb, 2020
Submission checks complete
On 27 Feb, 2020
Editor invited
On 27 Feb, 2020
First submitted
On 25 Feb, 2020
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Subject Areas
Toxicology
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A new preprint design is coming!
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See the published version of this preprint at Environmental Health.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Márcio Schneider Medeiros
Hospital de Clinicas de Porto Alegre
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4248-2277
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Environmental Health.
No community comments so far
Editorial decision: Accept
On 06 Jun, 2020
Editor assigned
On 05 Jun, 2020
Submission checks complete
On 04 Jun, 2020
Editor invited
On 04 Jun, 2020
No comments provided
Editorial decision: Minor revision
On 14 May, 2020
Review #2 received
Received 09 May, 2020
Reviewer #2 agreed
On 24 Apr, 2020
Reviewer #1 agreed
On 23 Apr, 2020
Review #1 received
Received 23 Apr, 2020
Reviewers invited
Invitations sent on 21 Apr, 2020
Editor assigned
On 20 Apr, 2020
Submission checks complete
On 19 Apr, 2020
Editor invited
On 19 Apr, 2020
Version 1
Posted 05 Mar, 2020
No comments provided
Editorial decision: Major revision
On 19 Mar, 2020
Review #2 received
Received 18 Mar, 2020
Reviewer #2 agreed
On 13 Mar, 2020
Review #1 received
Received 12 Mar, 2020
Reviewer #1 agreed
On 03 Mar, 2020
Editor assigned
On 28 Feb, 2020
Reviewers invited
Invitations sent on 28 Feb, 2020
Submission checks complete
On 27 Feb, 2020
Editor invited
On 27 Feb, 2020
First submitted
On 25 Feb, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Toxicology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Environmental Health.
Background Multiple studies have suggested that various pesticides are associated with a higher risk of developing Parkinson’s disease (PD) and may influence the progression of the disease. This study examines whether pesticide exposure influences the risk of mortality among patients with PD in Southern Brazil, when accounting for socioeconomic status, nicotine exposure, and caffeine exposure.
Methods 150 patients with idiopathic PD were enrolled from 2008-2013 and followed until 2019. In addition to undergoing a detailed neurologic evaluation, patients completed surveys regarding socioeconomic status and environmental exposures.
Results Twenty patients (13.3%) reported a history of occupational pesticide exposure with a median duration of exposure of 10 years (mean = 13.1, SD = 11.2). Patients with a history of occupational pesticide exposure had higher UPDRS-III scores, though there were no significant differences in regards to age, sex, disease duration, Charlson Comorbidity Index, and age at symptom onset. Patients with occupational pesticide exposure were more than twice as likely to die than their unexposed PD counterparts (HR = 2.32, 95% CI [1.15, 4.66], p = 0.22). Occupational pesticide exposure was also a significant predictor of death in a cox-proportional hazards model which included smoking and caffeine intake history and another which included several measures of socioeconomic status.
Conclusion In this prospective cohort study, we found an increased all-cause mortality risk in PD patients with occupational exposure to pesticides. More studies are needed to further analyze this topic with longer follow-up periods, more detailed exposure information, and more specific causes of mortality.
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
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