This study employs the SAM-based model combining with Multiplier Production Matrix and Field of Influence Approach. Under three Input-Output Transaction Table Matrices of the year 2005, 2010, and 2015, these approaches use to assess the dynamic tourism inter-industry linkages and structural economic changes in Cambodia. We find that the overall inter-industry connection is relatively low. The textile, other manufacturing, and transportation and communication are key sectors. They have the largest coefficient field of influence of changes in the economic system. Tourism has shifted to be a key sector in 2010 and 2015. However, its backward and forward linkages are still small. It is a relatively promising sector in terms of generating a large coefficient field of influence of changes, showing less strength of overall connection with other industries. This study may suggest that there would be a need for promoting, encouraging, and investing in key economic sectors. Policies intervention should focus on developing domestic tourism linkages and strengthening inter-industry ties for the success of diversifying tourism benefits to the local economy.