Effect of preoperative jaundice on long-term prognosis of gallbladder carcinoma with radical resection
Purposes: This study was designed to evaluate the long-term prognostic value of preoperative jaundice and explore which clinicopathological factor significantly influencing the long-term prognosis of gallbladder carcinoma (GBC) after radical resection (R0).
Methods: A total of 267 GBC patients who underwent R0 resection between January 2004 and December 2014 were enrolled, including 54 patients with preoperative jaundice and 213 patients without jaundice. The clinicopathological parameters between the two groups were compared, and the correlation between preoperative jaundice and the long-term prognosis was furtherly analyzed.
Results: Unilateral and multivariate analyses of 267 GBC patients showed that the depth of tumor invasion (pT stage), lymphatic metastasis, and hepatic invasion were independent prognostic factors. In terms of the 54 GBC patients with preoperative jaundice, univariate and multivariate analysis showed that only pT stage was an independent factor for prognosis. Furthermore, the intraoperative blood transfusion and pT stage were significant different between long-term survival (survival for more than 3 years) and those who died within 3 years (P<0.05).
Conclusion: Preoperative jaundice was not the independent factor affecting the poor long-term prognosis of gallbladder carcinoma after R0 resection. The pT stage was the only long-term prognostic factor in all GBC patients with and without preoperative jaundice.
Figure 1
Posted 16 Jun, 2020
On 05 Sep, 2020
On 15 Jun, 2020
On 14 Jun, 2020
On 14 Jun, 2020
On 17 May, 2020
Received 15 May, 2020
Received 11 May, 2020
Received 09 May, 2020
On 07 May, 2020
On 07 May, 2020
On 05 May, 2020
Received 05 May, 2020
On 04 May, 2020
Received 06 Mar, 2020
Invitations sent on 05 Mar, 2020
On 05 Mar, 2020
On 02 Mar, 2020
On 01 Mar, 2020
On 01 Mar, 2020
On 28 Feb, 2020
Effect of preoperative jaundice on long-term prognosis of gallbladder carcinoma with radical resection
Posted 16 Jun, 2020
On 05 Sep, 2020
On 15 Jun, 2020
On 14 Jun, 2020
On 14 Jun, 2020
On 17 May, 2020
Received 15 May, 2020
Received 11 May, 2020
Received 09 May, 2020
On 07 May, 2020
On 07 May, 2020
On 05 May, 2020
Received 05 May, 2020
On 04 May, 2020
Received 06 Mar, 2020
Invitations sent on 05 Mar, 2020
On 05 Mar, 2020
On 02 Mar, 2020
On 01 Mar, 2020
On 01 Mar, 2020
On 28 Feb, 2020
Purposes: This study was designed to evaluate the long-term prognostic value of preoperative jaundice and explore which clinicopathological factor significantly influencing the long-term prognosis of gallbladder carcinoma (GBC) after radical resection (R0).
Methods: A total of 267 GBC patients who underwent R0 resection between January 2004 and December 2014 were enrolled, including 54 patients with preoperative jaundice and 213 patients without jaundice. The clinicopathological parameters between the two groups were compared, and the correlation between preoperative jaundice and the long-term prognosis was furtherly analyzed.
Results: Unilateral and multivariate analyses of 267 GBC patients showed that the depth of tumor invasion (pT stage), lymphatic metastasis, and hepatic invasion were independent prognostic factors. In terms of the 54 GBC patients with preoperative jaundice, univariate and multivariate analysis showed that only pT stage was an independent factor for prognosis. Furthermore, the intraoperative blood transfusion and pT stage were significant different between long-term survival (survival for more than 3 years) and those who died within 3 years (P<0.05).
Conclusion: Preoperative jaundice was not the independent factor affecting the poor long-term prognosis of gallbladder carcinoma after R0 resection. The pT stage was the only long-term prognostic factor in all GBC patients with and without preoperative jaundice.
Figure 1