DOI: https://doi.org/10.21203/rs.3.rs-1628977/v1
Objective: To evaluate the association between Nonalcoholic fatty liver disease (NAFLD) and lumbar spine bone mineral density (BMD) in type 2 diabetes mellitus (T2DM).
Methods: The lumbar BMD of 1088 subjects was measured using dual-energy X-ray absorptiometry (DXA). Liver fat content was quantified via ultrasound. According to clinical diagnosis, subjects were divided into T2DM and non diabetes groups. The groups were further divided into NAFLD and non- NAFLD groups. Student’s t-test assessed the differences in BMD between the NAFLD and non-NAFLD groups. Multivariable linear regression analysis adjusted for confounders was performed to evaluate the association between lumbar BMD and NAFLD.
Results: The lumbar BMD in the T2DM group and the non diabetes group was higher in the NAFLD group than in the non-NAFLD group (P<0.001). Multivariate regression analysis in the T2DM group showed that after adjusting for confounders, the association between lumbar spine BMD and NAFLD remained (P=0.027). In the non diabetes group, after adjusting for confounders, the association between NAFLD and lumbar spine BMD disappeared.
Conclusions: The lumbar BMD of NAFLD patients is higher than that of non-NAFLD. After adjusting for confounding factors, lumbar BMD was associated with NAFLD in T2DM patients but not in non diabetes patients.