Three SARS-CoV-2 recombinants identified in Brazilian children

doi:10.21203/rs.3.rs-1641864/v1

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Three SARS-CoV-2 recombinants identified in Brazilian children

https://doi.org/10.21203/rs.3.rs-1641864/v1

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posted 13 May, 2022

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Since the emergence of the variant of concern (VOC) B.1.1.529 (Omicron) in November 2021¹, nearly 100 sublineages have been assigned by Pango. Recently, the co-circulation of Omicron and Delta lineages, as well as its diverse set of sublineages, has brought to attention the identification of several recombinant events. A putative new recombinant and two XE recombinants were identified in children by the GENOV surveillance program (https://dasa.com.br/en/genov/) from Dasa, Brazil. All three children haven’t traveled abroad nor their relatives, indicating that the infections by recombinants likely occurred in São Paulo city.

Virology

SARS-CoV-2

recombinant

omicron

Ethics approval:

The COVID-19 Genomic surveillance project that identified these 3 recombinants described in the manuscript was approved by the Ethical Committe from Hospital Nove de Julho, CAAE 45540421.0.0000.5455.

Competing interests:

The authors declare no competing interests.

Acknowledgments

We are grateful to Rodrigo Guarischi Souza, Rodrigo Salazar da Silva, Angélica Hristov, Laryssa Accorsi Sassi, and Rafaela Belucci Rosa Leal for the technical excellence on the Genov sequencing process and the support of Flavia Paiva Lopes from the Instituto de Ensino e Pesquisa da Dasa (IEPD).

Funding

This study was funded by Dasa and KFW DEG Bank (Grant G0512).

Classification of Omicron (B.1.1.529): SARS-CoV–2 Variant of Concern. https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov–2-variant-of-concern.
Rambaut, A. et al. A dynamic nomenclature proposal for SARS-CoV–2 lineages to assist genomic epidemiology. Nat. Microbiol. 5, 1403–1407 (2020).
O’Toole, Á. et al. Assignment of epidemiological lineages in an emerging pandemic using the pangolin tool. Virus Evol. 7, veab064 (2021).
Statement of Nomenclature Rules – Pango Network. https://www.pango.network/the-pango-nomenclature-system/statement-of-nomenclature-rules/.
Khare, S. et al. GISAID’s Role in Pandemic Response. China CDC Wkly. 3, 1049–1051 (2021).
Turakhia, Y. et al. Ultrafast Sample placement on Existing tRees (UShER) enables real-time phylogenetics for the SARS-CoV–2 pandemic. Nat. Genet. 53, 809–816 (2021).
Chen, C. et al. CoV-Spectrum: analysis of globally shared SARS-CoV–2 data to identify and characterize new variants. Bioinformatics 38, 1735–1737 (2022).
Pango lineages: guidelines for suggesting novel and recombinant lineages – Pango Network. https://www.pango.network/pango-lineages-guidelines-for-suggesting-novel-and-recombinant-lineages/.

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Three SARS-CoV-2 recombinants identified in Brazilian children

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